IndraLab

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Sal-miR-1 decreases the amount of OTUD7B. 3 / 3
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"Sal-miR-1 and Sal-miR-1 obviously decreased the expression of OTUD7B and intimal hyperplasia induced by vascular injury, suggesting that OTUD7B plays the pro inflammatory and pro proliferation effects for VSMCs in response to vascular injury."
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"Next, we confirmed that Sal-miR-1 or Sal-miR-3 alone or together significantly inhibited the expression of OTUD7B mRNA and protein, but did not affect KLF3 and KLF10 expression, indicating the specificity of these two miRNA target recognition (XREF_SUPPLEMENTARY B-C)."
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"Remarkably, Sal-miR-1 and 3 increased the expression levels of NMHC IIA by inhibiting OTUD7B expression and thus reducing KLF4 protein levels."
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