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"Moreover , OTUD7B inhibition also largely increased the inhibitory effects of Sal-miR-1 and 3 on thrombin-induced VSMC migration ( Figure 3O ) and adhesion ( Figure 3P ) , accompanied by a corresponding change in actin cytoskeleton morphology ( Figure 3N ) and the expression of VCAM-1 and ICAM-1 ( Figure 3M ) ."