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OTUD7B inhibits autophagy. 4 / 4
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"Our animal experiments revealed that Cezanne overexpression in mice reversed DOX-induced cardiomyocyte apoptosis, autophagy, oxidative stress and hypertrophy."
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"We found that Cezanne overexpression in NRCMs activated AKT/mTOR to reduce apoptosis, autophagy and oxidative stress; this mechanism of Cezanne was also verified in animal experiments."
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"Subsequent functional experiments found that Cezanne knockdown in NRCMs promoted DOX-induced apoptosis, autophagy and oxidative stress, while Cezanne overexpression protected NRCMs from these damages [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with the data in vitro , the Western blot results showed that autophagy dysregulation was reversed by AAV9- Cezanne injection, confirmed by the decrease of ATG5 and LC3Ⅱ and the increase of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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