IndraLab

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OTUD7B activates NFkappaB. 5 / 6
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"The Otud7b deficiency greatly enhanced the NF-kappaB activation by agonistic anti-LTbetaR and anti-CD40 antibodies or BAFF (XREF_FIG), a result that was not due to differential expression of the receptors (XREF_SUPPLEMENTARY)."
23334419
sparser
"This study sheds light on the molecular mechanism of negative regulation of NF-κB activation by Cezanne."
28817177
sparser
"Mutation at these sites disrupted the recruitment of Cezanne to activated TNFR complex and dramatically reduced the inhibition of NF-κB activation by Cezanne."
28817177
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"Other proteins that modulate NFkappaB signaling were also downregulated, including ubiquitin conjugating enzyme E2 V1 (UBE2V1), which activates NFkappaB, and OTU deubiquitinase 7B (OTUD7B), a clock regulated protein that downregulates the non canonical NF-kappaB pathway."
30971946
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"Otud7b deficiency in mice has no appreciable effect on canonical NF-kappaB activation but causes hyper-activation of noncanonical NF-kappaB."
23334419