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Statements

OTUD7B activates CD4. 3 / 3
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"Indeed, in vitro activated naive Otud7b -/- T cells produced less IL-2, and aged Otud7b deficient mice had increased frequencies and numbers of naive CD4 T cells, whereas those of effector-memory phenotype were decreased."
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"In this regard, T cells are essential to eradicate L. monocytogenes from the infected host, and T cell intrinsic expression of OTUD7B augments the protective Listeria -specific CD4 and CD8 T cell resp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, at an older age (12 mo old), the Otud7b -/- mice had significantly reduced frequency and absolute numbers of memory like T cells and concomitantly increased frequency and numbers of naive T cells in both CD4 + and CD8 + T cell populations (XREF_FIG)."
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