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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUD7B activates CD4. 2 / 2

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"Indeed, in vitro activated naive Otud7b -/- T cells produced less IL-2, and aged Otud7b deficient mice had increased frequencies and numbers of naive CD4 T cells, whereas those of effector-memory phenotype were decreased."

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"However, at an older age (12 mo old), the Otud7b -/- mice had significantly reduced frequency and absolute numbers of memory like T cells and concomitantly increased frequency and numbers of naive T cells in both CD4 + and CD8 + T cell populations (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...