IndraLab

Statements

OTUD1 affects SMURF1
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OTUD1 binds SMURF1.
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SMURF1 binds OTUD1. 9 / 9
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"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1, prevent its self-ubiquitination degradation, and upregulate its protein level; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS, and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination (possibly k63-linked) and enzyme activity of Smurf1 ( xref ) ( xref , xref )."
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"RNA virus infection promotes the interaction between OTUD1 and Smurf1, and binding of Smurf1 to MAVS/TRAF3/TRAF6."
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"We found that Smurf1 was able to interact with OTUD1 ( xref )."
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"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1, prevent its self-ubiquitination degradation, and upregulate its protein level; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS, and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination (possibly k63-linked) and enzyme activity of Smurf1 (Table 1) (47, 49)."
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"We found that SeV infection promoted interaction between OTUD1 and Smurf1 (XREF_FIG)."
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"RNA virus infection promotes the interaction between OTUD1 and Smurf1, and binding of Smurf1 to MAVS/TRAF3/TRAF6."
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"Given that RNA viruses activate OTUD1 expression and subsequent Smurf1 upregulation, we further analyze whether OTUD1 interacts with Smurf1, and how Smurf1 is able to affect MAVS/TRAF3/TRAF6 proteins during RNA virus infection."
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"In this study, we reveal that RNA virus infection activates expression of OTUD1, which in turn interacts with Smurf1 and upregulates Smurf1 protein levels by deubiquitination effects."
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"Given that RNA viruses activate OTUD1 expression and subsequent Smurf1 upregulation, we further analyze whether OTUD1 interacts with Smurf1, and how Smurf1 is able to affect MAVS/TRAF3/TRAF6 proteins during RNA virus infection."
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SMURF1 binds OTUD1 and Klk9. 1 / 1
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"We found that SeV infection promoted interaction between OTUD1 and Smurf1 ( xref )."
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OTUD1 increases the amount of SMURF1.
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OTUD1 increases the amount of SMURF1. 4 / 4
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"For example, OTUD1 upregulates the protein levels of intracellular Smurf1 by removing the K48-linked polyubiquitin chains of Smurf1, and RNA virus infection promotes the binding of Smurf1 to MAVS, TRAF3, and TRAF6, which leads to ubiquitination-dependent degradation of the three proteins and subsequent potent inhibition of IFNs production (64)."
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"And OTUD1 upregulates Smurf1 protein levels by removing ubiquitination of Smurf1."
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"Thus, these data demonstrate that OTUD1 positively regulates cellular levels of Smurf1 by deubiquitination effects."
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"Furthermore, OTUD1 upregulates protein levels of intracellular Smurf1 by removing Smurf1 ubiquitination."
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Modified OTUD1 increases the amount of SMURF1. 4 / 4
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"RNA virus infection promotes NF-kappaB-dependent expression of OTUD1 that upregulates Smurf1 protein levels."
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"In this study, we reveal that RNA virus infection activates expression of OTUD1, which in turn interacts with Smurf1 and upregulates Smurf1 protein levels by deubiquitination effects."
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"We further found that OTUD1 overexpression upregulated protein level of Smurf1, rather than Smurf2 (XREF_SUPPLEMENTARY)."
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"Overexpression of OTUD1 upregulated exogenous Smurf1 protein levels in a dose dependent manner (XREF_FIG)."
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OTUD1 ubiquitinates SMURF1.
| 2
OTUD1 leads to the ubiquitination of SMURF1. 2 / 2
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"Furthermore, OTUD1 upregulates protein levels of intracellular Smurf1 by removing Smurf1 ubiquitination."
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"And OTUD1 upregulates Smurf1 protein levels by removing ubiquitination of Smurf1."
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OTUD1 activates SMURF1.
| 2
OTUD1 activates SMURF1. 2 / 2
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"RNA virus induced OTUD1 protein regulates Smurf1 ubiquitination and increases the level of Smurf1 protein."
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"Next, we analyzed the deubiquitination types of Smurf1 mediated by OTUD1 using two ubiquitin mutants, Ub-R48K (all lysines in Ub are mutated to arginines except lysine 48 residue) and Ub-R63K (all lysines in Ub are mutated to arginines except lysine 63 residue)."
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OTUD1 deubiquitinates SMURF1.
| 1
OTUD1 leads to the deubiquitination of SMURF1. 1 / 1
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"Furthermore, OTUD1 induced upregulation of the E3 ubiquitin ligase Smurf1 by deubiquitinating Smurf1, and Smurf1 degraded MAVS in MDBK cells in a ubiquitination dependent manner, ultimately inhibiting IFN-I production."
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OTUD1 affects TP53
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OTUD1 binds TP53.
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TP53 binds OTUD1. 5 / 6
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"Moreover, we observed that OTUD1 directly interacted with p53."
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"Moreover, we observed that OTUD1 directly interacted with p53."
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No evidence text available
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"Moreover, we observed that OTUD1 directly interacted with p53."
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OTUD1 deubiquitinates TP53.
1 | 1 2
OTUD1 deubiquitinates TP53. 4 / 4
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"OTUD1, OTUD5 and USP11 directly deubiquitinating p53 and functional proteins were required for p53 stabilization [XREF_BIBR - XREF_BIBR]."
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"Our results showed that OTUD1 deubiquitinated p53 and that functional OTUD1 was required for p53 stabilization."
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"Our results showed that OTUD1 deubiquitinated p53 and that functional OTUD1 was required for p53 stabilization."
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"Review"
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OTUD1 activates TP53.
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OTUD1 activates TP53. 1 / 2
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"OTUD1 overexpression increased p53 stability, whereas OTUD1 knockdown decreased p53 stability."
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OTUD1 affects MAVS
| 10 2
OTUD1 decreases the amount of MAVS.
| 4
OTUD1 decreases the amount of MAVS. 3 / 3
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"OTUD1 negatively regulates protein levels of MAVS, TRAF3, and TRAF6."
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"Together, these data suggest that OTUD1 negatively regulates protein levels of MAVS, TRAF3, and TRAF6."
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"In this study, we uncovered that OTUD1 can downregulate protein levels of MAVS, TRAF3 and TRAF6."
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Modified OTUD1 decreases the amount of MAVS. 1 / 1
| 1
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"However, we noticed that OTUD1 overexpression gradually downregulated the levels of MAVS, TRAF3, and TRAF6 (XREF_FIG), which is consistent with the observation that OTUD1 overexpression inhibits the induction of type I IFNs and proinflammatory cytokines."
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OTUD1 binds MAVS.
| 1 2
OTUD1 binds MAVS. 2 / 2
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"To further identify the signaling proteins targeted by OTUD1, the interaction between OTUD1 and MAVS was first analyzed."
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"Our data showed that OTUD1 was able to interact with MAVS ( xref )."
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TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
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"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
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OTUD1 inhibits MAVS.
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OTUD1 inhibits MAVS. 2 / 2
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"These data indicate that OTUD1 inhibits the IFNs antiviral response downstream of MAVS and upstream of TBK1."
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"In the presence of MG132, the ability of OTUD1 to downregulate MAVS (XREF_FIG), or TRAF3 (XREF_FIG), or TRAF6 (XREF_FIG) was largely inhibited."
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OTUD1 activates MAVS.
| 2
OTUD1 activates MAVS. 2 / 2
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"Therefore, we tried to analyze whether Smurf1 could be required for OTUD1 mediated downregulation of MAVS."
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"Our data showed that knockdown of Smurf1 significantly inhibited OTUD1 mediated MAVS downregulation (XREF_FIG)."
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OTUD1 deubiquitinates MAVS.
| 1
OTUD1 leads to the deubiquitination of MAVS. 1 / 1
| 1
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"Furthermore, OTUD1 induced upregulation of the E3 ubiquitin ligase Smurf1 by deubiquitinating Smurf1, and Smurf1 degraded MAVS in MDBK cells in a ubiquitination dependent manner, ultimately inhibiting IFN-I production."
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SMURF1 affects OTUD1
| 4 7
SMURF1 binds OTUD1.
| 3 7
SMURF1 binds OTUD1. 9 / 9
| 3 6
sparser
"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1, prevent its self-ubiquitination degradation, and upregulate its protein level; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS, and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination (possibly k63-linked) and enzyme activity of Smurf1 ( xref ) ( xref , xref )."
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"RNA virus infection promotes the interaction between OTUD1 and Smurf1, and binding of Smurf1 to MAVS/TRAF3/TRAF6."
29734366
sparser
"We found that Smurf1 was able to interact with OTUD1 ( xref )."
29734366
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"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1, prevent its self-ubiquitination degradation, and upregulate its protein level; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS, and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination (possibly k63-linked) and enzyme activity of Smurf1 (Table 1) (47, 49)."
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"We found that SeV infection promoted interaction between OTUD1 and Smurf1 (XREF_FIG)."
29734366
sparser
"RNA virus infection promotes the interaction between OTUD1 and Smurf1, and binding of Smurf1 to MAVS/TRAF3/TRAF6."
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"Given that RNA viruses activate OTUD1 expression and subsequent Smurf1 upregulation, we further analyze whether OTUD1 interacts with Smurf1, and how Smurf1 is able to affect MAVS/TRAF3/TRAF6 proteins during RNA virus infection."
29734366
sparser
"In this study, we reveal that RNA virus infection activates expression of OTUD1, which in turn interacts with Smurf1 and upregulates Smurf1 protein levels by deubiquitination effects."
29734366
sparser
"Given that RNA viruses activate OTUD1 expression and subsequent Smurf1 upregulation, we further analyze whether OTUD1 interacts with Smurf1, and how Smurf1 is able to affect MAVS/TRAF3/TRAF6 proteins during RNA virus infection."
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SMURF1 binds OTUD1 and Klk9. 1 / 1
| 1
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"We found that SeV infection promoted interaction between OTUD1 and Smurf1 ( xref )."
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SMURF1 activates OTUD1.
| 1
SMURF1 activates OTUD1. 1 / 1
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"Interestingly, Smurf1 knockdown also remarkably blocked OTUD1 mediated downregulation of both TRAF3 (XREF_FIG) and TRAF6 (XREF_FIG)."
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OTUD1 affects TYK2
| 9 2
OTUD1 binds TYK2.
| 2 2
TYK2 binds OTUD1. 4 / 4
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"Consistently, the spleen tissues of depression model mice displayed lower AHI1 levels and less interaction between OTUD1 and Tyk2 than those of normal mice (Fig. 4h)."
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"Consistently, the spleen tissues of depression model mice displayed lower AHI1 levels and less interaction between OTUD1 and Tyk2 than those of normal mice (Fig.  xref )."
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"We noticed that AHI1 did not strongly affect OTUD1 protein levels (Fig.  xref ) but affected the interaction between OTUD1 and Tyk2, as shown by the abolishment of the OTUD1-Tyk2 interaction upon AHI1 knockout in primary macrophages (Fig.  xref )."
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"We noticed that AHI1 did not strongly affect OTUD1 protein levels (Fig. 4f) but affected the interaction between OTUD1 and Tyk2, as shown by the abolishment of the OTUD1-Tyk2 interaction upon AHI1 knockout in primary macrophages (Fig. 4g)."
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OTUD1 increases the amount of TYK2.
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OTUD1 increases the amount of TYK2. 3 / 3
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"Importantly, OTUD1 knockdown inhibited the AHI1-mediated upregulation of Tyk2 levels (Fig. 4e), suggesting that OTUD1 is essential for the AHI1-mediated regulation of Tyk2 protein levels."
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"Importantly, AHI1 deficiency inhibited OTUD1-mediated both downregulation of Tyk2 ubiquitination (Fig. 5c) and upregulation of Tyk2 protein levels (Supplementary information, Fig. S5g), suggesting that OTUD1 regulates Tyk2 ubiquitination and protein levels dependently on AHI1.OTUD1 has been reported to be able to regulate both K48-linked and K63-linked ubiquitination of protein substrates."
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"We found that OTUD1 overexpression increased Tyk2 protein levels in a dose-dependent manner (Supplementary information, Fig. S5b), while OTUD1 knockout in primary macrophages dramatically reduced Tyk2 protein levels (Fig. 4d)."
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OTUD1 ubiquitinates TYK2.
| 1
OTUD1 leads to the ubiquitination of TYK2. 1 / 1
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"Importantly, AHI1 deficiency inhibited OTUD1-mediated both downregulation of Tyk2 ubiquitination (Fig. 5c) and upregulation of Tyk2 protein levels (Supplementary information, Fig. S5g), suggesting that OTUD1 regulates Tyk2 ubiquitination and protein levels dependently on AHI1.OTUD1 has been reported to be able to regulate both K48-linked and K63-linked ubiquitination of protein substrates."
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OTUD1 deubiquitinates TYK2.
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OTUD1 leads to the deubiquitination of TYK2. 1 / 1
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"In line with this, OTUD1 deficiency in both primary macrophages (Fig. 5b) and MEFs (Supplementary information, Fig. S5d), as well as A549 cells (Supplementary information, Fig. S5e), markedly improved Tyk2 ubiquitination levels, whereas OTUD1 overexpression inhibited Tyk2 ubiquitination (Fig. 5c; Supplementary information, Fig. S5f)."
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OTUD1 decreases the amount of TYK2.
| 1
OTUD1 decreases the amount of TYK2. 1 / 1
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"We found that OTUD1 overexpression increased Tyk2 protein levels in a dose-dependent manner (Supplementary information, Fig. S5b), while OTUD1 knockout in primary macrophages dramatically reduced Tyk2 protein levels (Fig. 4d)."
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OTUD1 activates TYK2.
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OTUD1 activates TYK2. 1 / 1
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"It will be interesting to clarify the signaling crosstalk between different types of cells stimulated by different hormones in the future.In summary, we found that depression-elevated AVP induces AHI1 reduction in macrophages, which further disrupts the deubiquitinase OTUD1-mediated stabilization of cellular Tyk2, thus attenuating basal IFN-I signaling and host antiviral immune defense (Fig. 8h)."
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OTUD1 affects TRAF6
| 8 3
OTUD1 decreases the amount of TRAF6.
| 4
OTUD1 decreases the amount of TRAF6. 3 / 3
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"OTUD1 negatively regulates protein levels of MAVS, TRAF3, and TRAF6."
29734366
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"Together, these data suggest that OTUD1 negatively regulates protein levels of MAVS, TRAF3, and TRAF6."
29734366
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"In this study, we uncovered that OTUD1 can downregulate protein levels of MAVS, TRAF3 and TRAF6."
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Modified OTUD1 decreases the amount of TRAF6. 1 / 1
| 1
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"Similarly, OTUD1 overexpression lowered protein levels of TRAF3 (XREF_FIG) and TRAF6 (XREF_FIG)."
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OTUD1 binds TRAF6.
| 1 3
TRAF3 binds TRAF6 and OTUD1. 2 / 2
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"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
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"Results showed that OTUD1 was also capable of interacting with both TRAF3 ( xref ) and TRAF6 ( xref )."
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TRAF6 binds OTUD1. 1 / 1
| 1
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"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
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TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
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"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
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OTUD1 inhibits TRAF6.
| 3
OTUD1 inhibits TRAF6. 2 / 2
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"Interestingly, Smurf1 knockdown also remarkably blocked OTUD1 mediated downregulation of both TRAF3 (XREF_FIG) and TRAF6 (XREF_FIG)."
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"In the presence of MG132, the ability of OTUD1 to downregulate MAVS (XREF_FIG), or TRAF3 (XREF_FIG), or TRAF6 (XREF_FIG) was largely inhibited."
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Modified OTUD1 inhibits TRAF6. 1 / 1
| 1
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"However, we noticed that OTUD1 overexpression gradually downregulated the levels of MAVS, TRAF3, and TRAF6 (XREF_FIG), which is consistent with the observation that OTUD1 overexpression inhibits the induction of type I IFNs and proinflammatory cytokines."
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OTUD1 affects TRAF3
| 8 3
OTUD1 decreases the amount of TRAF3.
| 4
OTUD1 decreases the amount of TRAF3. 3 / 3
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"In this study, we uncovered that OTUD1 can downregulate protein levels of MAVS, TRAF3 and TRAF6."
29734366
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"Together, these data suggest that OTUD1 negatively regulates protein levels of MAVS, TRAF3, and TRAF6."
29734366
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"OTUD1 negatively regulates protein levels of MAVS, TRAF3, and TRAF6."
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Modified OTUD1 decreases the amount of TRAF3. 1 / 1
| 1
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"Similarly, OTUD1 overexpression lowered protein levels of TRAF3 (XREF_FIG) and TRAF6 (XREF_FIG)."
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OTUD1 binds TRAF3.
| 1 3
TRAF3 binds TRAF6 and OTUD1. 2 / 2
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"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
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"Results showed that OTUD1 was also capable of interacting with both TRAF3 ( xref ) and TRAF6 ( xref )."
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TRAF3 binds OTUD1. 1 / 1
| 1
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"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
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TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
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"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
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OTUD1 inhibits TRAF3.
| 3
OTUD1 inhibits TRAF3. 2 / 2
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"In the presence of MG132, the ability of OTUD1 to downregulate MAVS (XREF_FIG), or TRAF3 (XREF_FIG), or TRAF6 (XREF_FIG) was largely inhibited."
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"Interestingly, Smurf1 knockdown also remarkably blocked OTUD1 mediated downregulation of both TRAF3 (XREF_FIG) and TRAF6 (XREF_FIG)."
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Modified OTUD1 inhibits TRAF3. 1 / 1
| 1
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"However, we noticed that OTUD1 overexpression gradually downregulated the levels of MAVS, TRAF3, and TRAF6 (XREF_FIG), which is consistent with the observation that OTUD1 overexpression inhibits the induction of type I IFNs and proinflammatory cytokines."
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OTUD1 affects SMAD7
1 | 8 2
OTUD1 deubiquitinates SMAD7.
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OTUD1 deubiquitinates SMAD7. 5 / 5
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"Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7"
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"OTUD1 deubiquitinates SMAD7 and sustains SMAD7 stability."
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"Further investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degradation."
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"To demonstrate that OTUD1 can directly deubiquitinate SMAD7, we performed in vitro deubiquitination assays."
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"This confirms that OTUD1 deubiquitinates SMAD7 in vitro."
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OTUD1 activates SMAD7.
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OTUD1 activates SMAD7. 4 / 4
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"The deubiquitinase OTUD1 was found to enable the antagonistic role of SMAD7 on TGF-beta signaling."
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"By doing so, OTUD1 enables SMAD7 function thereby antagonizing TGF-beta and SMAD signaling."
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"Ectopic expression of OTUD1-wt, but not OTUD1-CA, prolonged the half-life of endogenous SMAD7."
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"Given our results that OTUD1 enables SMAD7 and SMURF2 function, we examined whether OTUD1 misexpression can regulate TbetaRI levels at the cell surface, the location where intracellular signaling is initiated."
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OTUD1 binds SMAD7.
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OTUD1 binds SMAD7. 2 / 2
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"Moreover, Zhang et al. reported that OTUD1 binds with and stabilizes SMAD7 to repress the metastasis of breast cancer xref ."
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"OTUD1 associates with SMAD7 and deubiquitinates SMAD7 in vitro."
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OTUD1 affects MCL1
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OTUD1 binds MCL1. 10 / 10
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"The immunoprecipitation was used to determine the interaction between OTUD1 and MCL1."
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"Next, we tested whether OTUD1 interacts with MCL1."
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"The immunoprecipitation was used to determine the interaction between OTUD1 and MCL1."
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"These results indicate that OTUD1 interacts with MCL1 and regulates its stability through deubiquitination."
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"Since OTUD1 interacts with MCL1 and its enzymatic activity is required for MCL1 stability, then we tested whether OTUD1 influences the ubiquitination of MCL1."
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"We also found that OTUD1 interacted with MCL1 and removed the ubiquitin chain from it."
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"As shown in Fig.  xref a, Additional file xref : Fig. S3A, B, and S3B, OTUD1 interacts with MCL1 in both directions when co-transfected into cells."
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"OTUD1 interacts with MCL1 and promotes MCL1 deubiquitination."
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"OTUD1 interacts with MCL1 and promotes its deubiquitination."
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"OTUD1 interacts with MCL1 and promotes its deubiquitination."
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OTUD1 inhibits Neoplasm Metastasis.
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OTUD1 inhibits Neoplasm Metastasis. 8 / 8
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"Importantly, OTUD1 is lost in multiple types of human cancers and loss of OTUD1 increases metastasis in intracardial xenograft and orthotopic transplantation models, and correlates with poor prognosis among breast cancer patients."
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"Moreover, ectopic expression of OTUD1 significantly inhibited metastasis in control cells but did not show significant inhibitory effect in the SMAD7 knockout cells."
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"OTUD1 inhibits metastasis in transplantable mouse models."
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"Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7."
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"Therefore, our studies suggest that OTUD1 inhibits lung metastasis in transplantable mouse models."
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"Although cell transplantation induced bone metastasis to similar levels around day 21 post-injection, expression of OTUD1 wild-type (wt) beginning at day 21 significantly suppressed metastasis around day 35, which also led to increased mice survival."
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"Thus, OTUD1 represses breast cancer metastasis by mitigating TGF-beta-induced pro oncogenic responses via deubiquitination ofSMAD7."
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"Taken together, these analyses show that loss of OTUD1 strongly promotes breast cancer lung metastasis."
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OTUD1 activates Neoplasm Metastasis.
| 1
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"OTUD1 is a deubiquitinase and among its targets is SMAD7, and OTUD1 deficiency destabilizes SMAD7 and potentiates TGF-beta1-driven metastasis [XREF_BIBR]."
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OTUD1 affects Interferon
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OTUD1 inhibits Interferon.
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OTUD1 inhibits Interferon. 7 / 7
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"Hence , OTUD1 cleaves the K6-linked ubiquitin chain and leads to the disassociation of IRF3 from the promoter region of target genes , thereby attenuating type I IFN induction ."
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"Furthermore, OTUD1 inhibits type 1 IFN induction after virus infection through cleaving noncanonical K6-linked ubiquitination of IRF3 [83]."
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"OTUD1 negatively regulates the canonical NF-κB activation, apoptosis, and necroptosis, whereas OTUD1 upregulates the interferon (IFN) antiviral pathway."
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"The aforementioned results prove that Smurf1 is important for OTUD1 mediated inhibition of interferon antiviral response."
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"OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3."
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"Taken together, these results suggest that both Smurf1 and the deubiquitinase activity of OTUD1 are required for the downregulation of MAVS/TRAF3/TRAF6 signalosome proteins, which results in the OTUD1 mediated inhibition of interferon antiviral response."
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"] OTUD1 was also reported to inhibit IFN production during RNA virus infection ."
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OTUD1 activates Interferon.
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OTUD1 activates Interferon. 2 / 2
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"Both Smurf1 and the deubiquitinase activity of OTUD1 are required for OTUD1 mediated downregulation of MAVS/TRAF3/TRAF6 and inhibition of interferon antiviral response."
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"OTUD1 negatively regulates the canonical NF-κB activation, apoptosis, and necroptosis, whereas OTUD1 upregulates the interferon (IFN) antiviral pathway."
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OTUD1 affects AKT
| 1 6 1
OTUD1 inhibits AKT.
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OTUD1 inhibits AKT. 3 / 3
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"Moreover, analysis of OTUD1 RNA-seq data indicated that OTUD1 inhibition triggers the AKT and NF-kappa B pathways in renal cancer cells."
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"The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region."
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"OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs."
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OTUD1 activates AKT.
| 1 2
OTUD1 activates AKT. 3 / 3
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"Moreover, analysis of OTUD1 RNA-seq data indicated that OTUD1 inhibition triggers the AKT and NF-kappa B pathways in renal cancer cells."
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"We therefore show a mechanism by which OTUD1 modulates Akt activity and suggest a potential peptide-based cancer therapeutic strategy implemented by targeting the Akt PH domain."
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"We therefore show a mechanism by which OTUD1 modulates Akt activity and suggest a potential peptide-based cancer therapeutic strategy implemented by targeting the Akt PH domain ."
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OTUD1 dephosphorylates AKT.
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OTUD1 leads to the dephosphorylation of AKT. 1 / 1
| 1
reach
"Ectopic OTUD1 inhibits Akt phosphorylation; however, its deubiquitinase activity contributes only slightly to this effect."
36640312
OTUD1 binds AKT.
| 1
AKT binds OTUD1. 1 / 1
| 1
sparser
"Meanwhile, we also found that AKT did not bind with OTUD1 in 786-O cells ( xref A)."
35280681
OTUD1 affects YAP1
| 7
OTUD1 binds YAP1.
| 5
YAP1 binds OTUD1. 4 / 4
| 4
sparser
"Moreover, His-YAP protein purified from bacteria could be pulled down by GST-OTUD1, but not by GST, in an in vitro binding assay (Fig.  xref ), suggesting that OTUD1 directly interacts with YAP."
29891922
sparser
"This non-proteolytic ubiquitination can be reversed by the binding and interaction between deubiquitinase OTUD1 and YAP1; OTUD1 decreases YAP1 stability, and attenuates the cell proliferation and tumor-growth activity of YAP1 ( xref )."
32390875
sparser
"OTUD1 binds YAP and reverses its K63 ubiquitination."
29891922
sparser
"We further validated the interaction between OTUD1 and YAP in vivo and in vitro."
29891922
SKP2 binds YAP1 and OTUD1. 1 / 1
| 1
sparser
"K63-linked ubiquitination of YAP was upregulated in cells at low density (Fig.  xref ), which prompted us to examine whether cell density can influence the interaction of YAP with SKP2 or OTUD1."
29891922
OTUD1 ubiquitinates YAP1.
| 2
OTUD1 ubiquitinates YAP1. 2 / 2
| 2
sparser
"To further determine whether OTUD1 directly deubiquitinates YAP, we incubated purified OTUD1 and ubiquitinated YAP in a cell-free system."
29891922
sparser
"Using both the K63-specific mutant and the K63R mutant of ubiquitin, we found that of these four YAP-interacting DUBs, only OTUD1 clearly reduced K63-linked ubiquitination of YAP (Supplementary Fig.  xref ), while the other three DUBs (JOSD2, OTUD7B, and YOD1) substantially reduced non-K63-linked ubiquitination of YAP (Supplementary Fig.  xref )."
29891922
TP53 affects OTUD1
2 | 1 1 1
TP53 binds OTUD1. 5 / 6
2 | 1 1 1
sparser
"Moreover, we observed that OTUD1 directly interacted with p53."
28216291
trips
"Moreover, we observed that OTUD1 directly interacted with p53."
28216291
biogrid
No evidence text available
28216291
biogrid
No evidence text available
28216291
reach
"Moreover, we observed that OTUD1 directly interacted with p53."
28216291
OTUD1 affects type I IFNs
| 6
OTUD1 inhibits type I IFNs.
| 4
OTUD1 inhibits type I IFNs. 4 / 4
| 4
reach
"Consequently, OTUD1 negatively regulates RNA virus triggered production of type I IFNs and proinflammatory cytokines."
29734366
reach
"However, we noticed that OTUD1 overexpression gradually downregulated the levels of MAVS, TRAF3, and TRAF6 (XREF_FIG), which is consistent with the observation that OTUD1 overexpression inhibits the induction of type I IFNs and proinflammatory cytokines."
29734366
reach
"In the present study, we report that the OTU deubiquitinase 1 (OTUD1) negatively regulates RNA virus triggered production of type I IFNs and proinflammatory cytokines."
29734366
reach
"In a screen of deubiquitinases expression cloning library [XREF_BIBR, XREF_BIBR], we found that the deubiquitinase OTUD1 could inhibit RNA virus induced production of type I IFNs."
29734366
OTUD1 increases the amount of type I IFNs.
| 1
OTUD1 increases the amount of type I IFNs. 1 / 1
| 1
reach
"And Otud1 -/- mice produce higher levels of type I IFNs and are more resistant to RNA virus infection, when comparing to Otud1 +/+ mice (XREF_FIG)."
29734366
OTUD1 activates type I IFNs.
| 1
OTUD1 activates type I IFNs. 1 / 1
| 1
reach
"Following viral infection, OTUD1 knockout mice were shown to produce more type I IFNs and proinflammatory cytokines and were more resistant to lethal viral infection."
33511009
YAP1 affects OTUD1
| 5
YAP1 binds OTUD1. 4 / 4
| 4
sparser
"Moreover, His-YAP protein purified from bacteria could be pulled down by GST-OTUD1, but not by GST, in an in vitro binding assay (Fig.  xref ), suggesting that OTUD1 directly interacts with YAP."
29891922
sparser
"This non-proteolytic ubiquitination can be reversed by the binding and interaction between deubiquitinase OTUD1 and YAP1; OTUD1 decreases YAP1 stability, and attenuates the cell proliferation and tumor-growth activity of YAP1 ( xref )."
32390875
sparser
"OTUD1 binds YAP and reverses its K63 ubiquitination."
29891922
sparser
"We further validated the interaction between OTUD1 and YAP in vivo and in vitro."
29891922
SKP2 binds YAP1 and OTUD1. 1 / 1
| 1
sparser
"K63-linked ubiquitination of YAP was upregulated in cells at low density (Fig.  xref ), which prompted us to examine whether cell density can influence the interaction of YAP with SKP2 or OTUD1."
29891922
OTUD1 affects apoptotic process
| 1 3
OTUD1 activates apoptotic process.
| 1 2
reach
"Next, we confirmed that OTUD1 overexpression increased the cleavage of caspase-3 and PARP and subsequently increased apoptosis."
28216291
eidos
"OTUD1 knockdown inhibited melatonin-induced Bim upregulation and apoptosis in cancer cells ."
34826170
reach
"Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation."
34826170
OTUD1 inhibits apoptotic process.
| 1
OTUD1 inhibits apoptotic process. 1 / 1
| 1
reach
"OTUD1 negatively regulates the canonical NF-κB activation, apoptosis, and necroptosis, whereas OTUD1 upregulates the interferon (IFN) antiviral pathway."
35941131
OTUD1 affects TGFB
| 1 4
OTUD1 inhibits TGFB.
| 1 3
OTUD1 inhibits TGFB. 4 / 4
| 1 3
reach
"We next investigated the molecular mechanism by which OTUD1 inhibits TGF-beta and SMAD signaling."
29235476
reach
"OTUD1 causes suppression of TGF-beta downstream signals and EMT."
29235476
eidos
"Moreover , OTUD1 suppresses TGF-beta signaling and EMT in MCF10A cells expressing RAS and metastasis of breast cancer cells in mice , respectively , presumably through deubiquitylating SMAD7 thus enabling SMURF2 binding and subsequent TGFR turnover43 ."
30696809
reach
"Ectopic expression of OTUD1 could suppress TGF-beta signaling in control cells but barely showed effect in SMAD7 deficient cells; also knockdown of OTUD1 could promote TGF-beta signaling in control cells but not in SMAD7 deficient cells, suggesting thatinhibitory SMAD7 might be the major target of OTUD1 in the TGF-beta pathway."
29235476
OTUD1 deubiquitinates TGFB.
| 1
OTUD1 deubiquitinates TGFB. 1 / 1
| 1
reach
"Further investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degradation."
29235476
OTUD1 affects MAVS/TRAF3/TRAF6
| 5
OTUD1 ubiquitinates MAVS/TRAF3/TRAF6.
| 2
OTUD1 leads to the ubiquitination of MAVS/TRAF3/TRAF6. 1 / 1
| 1
reach
"Our above data demonstrated that OTUD1 promoted ubiquitination of MAVS/TRAF3/TRAF6, and downregulated their protein levels, suggesting that MAVS, TRAF3, and TRAF6 are not the direct targets of OTUD1 as a deubiquitinase."
29734366
Modified OTUD1 leads to the ubiquitination of MAVS/TRAF3/TRAF6 on K48. 1 / 1
| 1
reach
"And overexpression of OTUD1 promoted K48 linked ubiquitination of MAVS/TRAF3/TRAF6 (XREF_SUPPLEMENTARY), suggesting that OTUD1 promotes ubiquitination and degradation of MAVS/TRAF3/TRAF6."
29734366
OTUD1 inhibits MAVS/TRAF3/TRAF6.
| 1
OTUD1 inhibits MAVS/TRAF3/TRAF6. 1 / 1
| 1
reach
"As a consequence, OTUD1 inhibits MAVS/TRAF3/TRAF6 signalosome mediated production of type I IFNs and proinflammatory cytokines during RNA virus infection (XREF_FIG)."
29734366
OTUD1 deubiquitinates MAVS/TRAF3/TRAF6.
| 1
OTUD1 leads to the deubiquitination of MAVS/TRAF3/TRAF6. 1 / 1
| 1
reach
"And overexpression of OTUD1 promoted K48 linked ubiquitination of MAVS/TRAF3/TRAF6 (XREF_SUPPLEMENTARY), suggesting that OTUD1 promotes ubiquitination and degradation of MAVS/TRAF3/TRAF6."
29734366
OTUD1 activates MAVS/TRAF3/TRAF6.
| 1
OTUD1 activates MAVS/TRAF3/TRAF6. 1 / 1
| 1
reach
"Both Smurf1 and the deubiquitinase activity of OTUD1 are required for OTUD1 mediated downregulation of MAVS/TRAF3/TRAF6 and inhibition of interferon antiviral response."
29734366
OTUD1 affects EAF2
| 4 1
OTUD1 inhibits EAF2. 5 / 5
| 4 1
reach
"These results suggest that OTUD1 reduces the manifestation of cancer stem cell traits."
29235476
reach
"Combined, the in vitro and in vivo evidence in this study elucidates critical functions of OTUD1 in the termination of TGF-beta and SMAD-induced metastatic activation, indicating that OTUD1 restricts the EMT and cancer stem cell traits during metastasis."
29235476
sparser
"OTUD1 inhibits cancer stem cell traits."
29235476
reach
"OTUD1 inhibits cancer stem cell traits."
29235476
reach
"From our screen, we have identified that loss of OTUD1 enables breast cancer cells to undergo EMT and gain cancer stem cell traits thereby driving metastatic spread to distant organs, such as bone and lung."
29235476
TYK2 affects OTUD1
| 2 2
TYK2 binds OTUD1. 4 / 4
| 2 2
reach
"Consistently, the spleen tissues of depression model mice displayed lower AHI1 levels and less interaction between OTUD1 and Tyk2 than those of normal mice (Fig. 4h)."
35821088
sparser
"Consistently, the spleen tissues of depression model mice displayed lower AHI1 levels and less interaction between OTUD1 and Tyk2 than those of normal mice (Fig.  xref )."
35821088
sparser
"We noticed that AHI1 did not strongly affect OTUD1 protein levels (Fig.  xref ) but affected the interaction between OTUD1 and Tyk2, as shown by the abolishment of the OTUD1-Tyk2 interaction upon AHI1 knockout in primary macrophages (Fig.  xref )."
35821088
reach
"We noticed that AHI1 did not strongly affect OTUD1 protein levels (Fig. 4f) but affected the interaction between OTUD1 and Tyk2, as shown by the abolishment of the OTUD1-Tyk2 interaction upon AHI1 knockout in primary macrophages (Fig. 4g)."
35821088
TRAF6 affects OTUD1
| 1 3
TRAF3 binds TRAF6 and OTUD1. 2 / 2
| 2
sparser
"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
29734366
sparser
"Results showed that OTUD1 was also capable of interacting with both TRAF3 ( xref ) and TRAF6 ( xref )."
29734366
TRAF6 binds OTUD1. 1 / 1
| 1
reach
"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
29734366
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
TRAF3 affects OTUD1
| 1 3
TRAF3 binds TRAF6 and OTUD1. 2 / 2
| 2
sparser
"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
29734366
sparser
"Results showed that OTUD1 was also capable of interacting with both TRAF3 ( xref ) and TRAF6 ( xref )."
29734366
TRAF3 binds OTUD1. 1 / 1
| 1
reach
"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
29734366
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
reach
"From our screen, we have identified that loss of OTUD1 enables breast cancer cells to undergo EMT and gain cancer stem cell traits thereby driving metastatic spread to distant organs, such as bone and lung."
29235476
reach
"Combined, the in vitro and in vivo evidence in this study elucidates critical functions of OTUD1 in the termination of TGF-beta and SMAD-induced metastatic activation, indicating that OTUD1 restricts the EMT and cancer stem cell traits during metastasis."
29235476
reach
"OTUD1 causes suppression of TGF-beta downstream signals and EMT."
29235476
eidos
"Moreover , OTUD1 suppresses TGF-beta signaling and EMT in MCF10A cells expressing RAS and metastasis of breast cancer cells in mice , respectively , presumably through deubiquitylating SMAD7 thus enabling SMURF2 binding and subsequent TGFR turnover43 ."
30696809
OTUD1 affects STAT3
| 4
OTUD1 deubiquitinates STAT3.
| 2
OTUD1 deubiquitinates STAT3. 2 / 2
| 2
reach
"Mechanistically, OTUD1 bounds to the SH2 domain of STAT3 and causes deubiquitination of STAT3."
37153745
reach
"Conclusion: Cardiomyocyte OTUD1 promotes pathological cardiac remodeling and dysfunction by deubiquitinating STAT3."
37153745
OTUD1 inhibits STAT3.
| 1
OTUD1 inhibits STAT3. 1 / 1
| 1
reach
"Finally, OTUD1 overexpression by AAV9 vector increases Ang II-induced cardiac remodeling in mice and OTUD1-regulated responses can be inhibited by blocking STAT3."
37153745
OTUD1 activates STAT3.
| 1
OTUD1 activates STAT3. 1 / 1
| 1
reach
"OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes."
37153745
OTUD1 affects IFNB1
| 4
OTUD1 inhibits IFNB1.
| 3
OTUD1 inhibits IFNB1. 3 / 3
| 3
reach
"Our data showed that overexpression of OTUD1 inhibited the production of IFNbeta in response to SeV infection, whereas knockdown of Smurf1 largely blocked the negative regulation of OTUD1 on IFNbeta production (XREF_FIG), indicating that Smurf1 is required for OTUD1 mediated inhibition of interferon antiviral response."
29734366
reach
"During infection with SeV, overexpression of OTUD1-wild type obviously lowered the activity of IFNbeta promoter, whereas overexpression of OTUD1-CH mutant completely had no effect on the IFNbeta promoter activity (XREF_FIG), suggesting that the deubiquitinase activity of OTUD1 is important for OTUD1 mediated inhibition of IFNbeta production during viral infection."
29734366
reach
"The result showed that knockdown of OTUD1 promoted SeV induced IFNbeta production (XREF_FIG and XREF_SUPPLEMENTARY)."
29734366
OTUD1 activates IFNB1.
| 1
OTUD1 activates IFNB1. 1 / 1
| 1
reach
"At day 3 after VSV infection, Otud1 -/- mice produced much higher expression of IFNbeta and IL-6 mRNAs (XREF_FIG), and had much lower viral RNAs (XREF_FIG) in their lung tissue than did Otud1 +/+ mice."
29734366
OTUD1 affects Aurora-A
| 4
OTUD1 deubiquitinates Aurora-A.
| 2
OTUD1 deubiquitinates Aurora-A. 2 / 2
| 2
reach
"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A (XREF_FIG a)."
33669244
reach
"OTUD1, one of the final candidate DUBs for Aurora-A, bound to and deubiquitinated Aurora-A but its interaction with endogenous Aurora-A was much weaker than OTUD6A."
33669244
OTUD1 binds Aurora-A.
| 1
OTUD1 binds Aurora-A. 1 / 1
| 1
reach
"OTUD1, one of the final candidate DUBs for Aurora-A, bound to and deubiquitinated Aurora-A but its interaction with endogenous Aurora-A was much weaker than OTUD6A."
33669244
OTUD1 activates Aurora-A.
| 1
OTUD1 activates Aurora-A. 1 / 1
| 1
reach
"Moreover, OTUD1 was not able to increase the enzymatic activity of Aurora-A as much as OTUD6A."
33669244
OTUD1 affects AIFM1
| 4
OTUD1 binds AIFM1. 4 / 4
| 4
sparser
"Co‐IP assays showed that AIF selectively binds to the linker domain of OTUD1 (Figure S3C, Supporting Information), while OTUD1 associates with the NADH binding and Loop domains of AIF (Figure S3D, Supporting Information)."
33898171
sparser
"We next performed in vitro pulldown assays to investigate whether OTUD1 could directly bind to AIF."
33898171
sparser
"Among the proteins identified by MS, we focused on AIF (Figure  xref , xref ), which functions as an inducer of the caspase‐independent apoptosis pathway. [ xref ] To validate the interaction between OTUD1 and AIF, we first cotransfected Flag‐AIF and V5‐OTUD1 into 293T cells and performed immunoprecipitation using anti‐Flag magnetic beads."
33898171
sparser
"OTUD1 Interacts with AIF and Promotes AIF Nuclear Translocation."
33898171
TRAF6 affects TRAF3
| 3
TRAF3 binds TRAF6 and OTUD1. 2 / 2
| 2
sparser
"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
29734366
sparser
"Results showed that OTUD1 was also capable of interacting with both TRAF3 ( xref ) and TRAF6 ( xref )."
29734366
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
PTEN affects OTUD1
| 3
OTUD1 binds PTEN. 3 / 3
| 3
sparser
"Thus, we identified that the OTUD1-PTEN axis suppresses tumor growth and regulates the resistance of renal cancer to TKIs."
35280681
sparser
"Furthermore, OTUD1 interacts with PTEN and regulates its stability."
35280681
sparser
"First, the reciprocal immunoprecipitation assay indicated that endogenous OTUD1 interacts with PTEN in 786-O and ACHN cells (Fig. xref B, C)."
35280681
OTUD1 inhibits cell population proliferation. 3 / 3
| 3
reach
"Depletion of endogenous OTUD1 potentiated the capacity of RAS transformed MCF10A cells to form tumor organoids in 3D Matrigel but did not inhibit tumor cell survival and proliferation under standard 2D culture conditions."
29235476
reach
"Our results indicated that upregulation of OTUD1 expression inhibits TNBC cell proliferation and enhances its sensitivity to doxorubicin."
37257246
reach
"OTUD1 inhibited proliferation and migration of lung cancer cells in vitro."
36929488
OTUD1 affects SMURF2
| 3
OTUD1 activates SMURF2.
| 2
OTUD1 activates SMURF2. 2 / 2
| 2
reach
"In line with this, knockdown of OTUD1, which results in increased K33-poly-ubiquitin conjugation on SMAD7 K220, reduced the ability of SMURF2 to interact with SMAD7."
29235476
reach
"Given our results that OTUD1 enables SMAD7 and SMURF2 function, we examined whether OTUD1 misexpression can regulate TbetaRI levels at the cell surface, the location where intracellular signaling is initiated."
29235476
OTUD1 increases the amount of SMURF2.
| 1
Modified OTUD1 increases the amount of SMURF2. 1 / 1
| 1
reach
"We further found that OTUD1 overexpression upregulated protein level of Smurf1, rather than Smurf2 (XREF_SUPPLEMENTARY)."
29734366
OTUD1 affects SMAD3
| 3
OTUD1 deubiquitinates SMAD3.
| 2
OTUD1 deubiquitinates SMAD3. 2 / 2
| 2
reach
"Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3."
36579465
reach
"Our findings demonstrate that endothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3."
36579465
OTUD1 activates SMAD3.
| 1
OTUD1 activates SMAD3. 1 / 1
| 1
reach
"OTUD1-mediated SMAD3 activation regulates transcription of genes involved in vascular EndMT and remodeling in HUVECs."
36579465
OTUD1 affects SKP2
| 1 2
OTUD1 binds SKP2.
| 2
SKP2 binds YAP1 and OTUD1. 1 / 1
| 1
sparser
"K63-linked ubiquitination of YAP was upregulated in cells at low density (Fig.  xref ), which prompted us to examine whether cell density can influence the interaction of YAP with SKP2 or OTUD1."
29891922
SKP2 binds OTUD1. 1 / 1
| 1
sparser
"To assess whether the expression of SKP2 or OTUD1 is associated with clinical outcomes in breast cancer patients, we performed Kaplan–Meier (KM) plotter analysis of microarray datasets of human mammary tumors xref ."
29891922
OTUD1 inhibits SKP2.
| 1
OTUD1 inhibits SKP2. 1 / 1
| 1
reach
"Here, we report that YAP is subject to non proteolytic, K63 linked polyubiquitination by the SCF SKP2 E3 ligase complex (SKP2), which is reversed by the deubiquitinase OTUD1."
29891922
OTUD1 affects PTEN
| 3
OTUD1 binds PTEN. 3 / 3
| 3
sparser
"Thus, we identified that the OTUD1-PTEN axis suppresses tumor growth and regulates the resistance of renal cancer to TKIs."
35280681
sparser
"Furthermore, OTUD1 interacts with PTEN and regulates its stability."
35280681
sparser
"First, the reciprocal immunoprecipitation assay indicated that endogenous OTUD1 interacts with PTEN in 786-O and ACHN cells (Fig. xref B, C)."
35280681
OTUD1 affects IFNbeta promoter
| 3
OTUD1 inhibits IFNbeta promoter. 3 / 3
| 3
reach
"Results showed that knockdown of OTUD1 significantly enhanced activation of IFNbeta promoter during SeV infection (XREF_SUPPLEMENTARY), and overexpression of OTUD1 inhibited SeV induced activation of IFNbeta promoter (XREF_SUPPLEMENTARY)."
29734366
reach
"To further determine at what level in RLRs mediated antiviral signaling pathway OTUD1 blocked activation of IFNbeta promoter, three expression constructs (RIG-I, MAVS, or TBK1) were overexpressed in cells in the presence or absence of OTUD1."
29734366
reach
"The results showed that OTUD1 overexpression dramatically inhibited IFNbeta promoter activation driven by both RIG-I and MAVS (XREF_FIG), whereas IFNbeta promoter activation by TBK1 (XREF_FIG) was not inhibited by OTUD1 coexpression."
29734366
OTUD1 affects CARD9
| 1 1 1
OTUD1 binds CARD9.
| 1 1
CARD9 binds OTUD1. 2 / 2
| 1 1
sparser
"OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-κB and MAPK pathway."
33789983
reach
"OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-kappaB and MAPK pathway."
33789983
OTUD1 deubiquitinates CARD9.
| 1
OTUD1 deubiquitinates CARD9. 1 / 1
| 1
trips
"OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9."
33789983
OTUD1 affects BCL2L11
| 2 1
OTUD1 activates BCL2L11.
| 2
OTUD1 activates BCL2L11. 2 / 2
| 2
reach
"Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation."
34826170
reach
"In addition, melatonin-induced activation of Sp1 was found to be involved in OTUD1 upregulation at the transcriptional level, and pharmacological inhibition and genetic ablation of Sp1 (siRNA) interrupted melatonin-induced OTUD1-mediated Bim upregulation."
34826170
OTUD1 binds BCL2L11.
| 1
OTUD1 binds BCL2L11. 1 / 1
| 1
sparser
"OTUD1 directly interacted with Bim and inhibited its ubiquitination."
34826170
OTUD1 is modified
| 1 2
OTUD1 is ubiquitinated.
| 2
OTUD1 is ubiquitinated. 2 / 2
| 2
sparser
"Furthermore, we analyzed ubiquitination of endogenous Smurf1 in Otud1 +/+ and Otud1 -/- MEFs."
29734366
sparser
"Using both the K63-specific mutant and the K63R mutant of ubiquitin, we found that of these four YAP-interacting DUBs, only OTUD1 clearly reduced K63-linked ubiquitination of YAP (Supplementary Fig.  xref ), while the other three DUBs (JOSD2, OTUD7B, and YOD1) substantially reduced non-K63-linked ubiquitination of YAP (Supplementary Fig.  xref )."
29891922
OTUD1 is deubiquitinated.
| 1
OTUD1 is deubiquitinated. 1 / 1
| 1
trips
"The deubiquitination activity of OTUD1 was necessary for p53 stabilization, as confirmed using an inactive OTUD1 mutant (C320S OTUD1 mutant)."
28216291
MAVS affects OTUD1
| 1 2
OTUD1 binds MAVS. 2 / 2
| 1 1
reach
"To further identify the signaling proteins targeted by OTUD1, the interaction between OTUD1 and MAVS was first analyzed."
29734366
sparser
"Our data showed that OTUD1 was able to interact with MAVS ( xref )."
29734366
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
IRF3 affects OTUD1
| 2 1
IRF3 binds OTUD1.
| 1 1
OTUD1 binds IRF3. 1 / 1
| 1
sparser
"OTUD1 interacts with IRF3 to remove the K63-linked poly-ubiquitin chains on IRF3 and to suppress the interferon activity."
32151092
OTUD1 binds IRF3 and K63. 1 / 1
| 1
reach
"As a deubiquitinase, OTUD1 directly interacts with transcription factor IRF3 and removes the K63 linked poly-ubiquitin chains on IRF3 Lysine 98, which inhibits IRF3 nuclear translocation and transcriptional activity."
30100102
IRF3 activates OTUD1.
| 1
IRF3 activates OTUD1. 1 / 1
| 1
reach
"Consistent with the former investigations that IRF3 promoted inflammatory responses in LPS induced sepsis, Otud1 -/- mice were more susceptible to LPS stimulation."
32075857
Valproic acid affects OTUD1
2 |
Valproic acid methylates OTUD1.
1 |
Valproic acid methylates OTUD1. 1 / 1
1 |
ctd
No evidence text available
29154799
Valproic acid increases the amount of OTUD1.
1 |
Valproic acid increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
29154799
Tetrachloromethane increases the amount of OTUD1. 2 / 2
2 |
ctd
No evidence text available
27339419
ctd
No evidence text available
31150632
Phenylmercury acetate decreases the amount of OTUD1. 2 / 2
2 |
ctd
No evidence text available
27188386
ctd
No evidence text available
26272509
Paracetamol affects OTUD1
2 |
Paracetamol increases the amount of OTUD1. 2 / 2
2 |
ctd
No evidence text available
21420995
ctd
No evidence text available
29067470
Melatonin affects OTUD1
| 2
Melatonin activates OTUD1. 2 / 2
| 2
reach
"Melatonin-induced OTUD1 upregulation caused deubiquitnation at the lysine 3 residue of Bim, resulting in its stabilization."
34826170
reach
"Furthermore, melatonin reduced tumor growth and induced upregulation of OTUD1 and Bim in a mouse xenograft model."
34826170
Hsa-miR-19b-3p affects OTUD1
2 |
Hsa-miR-19b-3p decreases the amount of OTUD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-181a-5p affects OTUD1
2 |
Hsa-miR-181a-5p decreases the amount of OTUD1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
17612493
biopax:mirtarbase
No evidence text available
20371350
Cyclosporin A affects OTUD1
2 |
Cyclosporin A increases the amount of OTUD1. 2 / 2
2 |
ctd
No evidence text available
20106945
ctd
No evidence text available
25562108
Bisphenol A affects OTUD1
2 |
Bisphenol A increases the amount of OTUD1.
1 |
Bisphenol A increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
26496021
Bisphenol A decreases the amount of OTUD1.
1 |
Bisphenol A decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
25181051
Benzo[a]pyrene affects OTUD1
2 |
Benzo[a]pyrene increases the amount of OTUD1.
1 |
Benzo[a]pyrene increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
20064835
Benzo[a]pyrene decreases the amount of OTUD1.
1 |
Benzo[a]pyrene decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
19770486
All-trans-retinoic acid increases the amount of OTUD1.
1 |
All-trans-retinoic acid increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
23724009
All-trans-retinoic acid decreases the amount of OTUD1.
1 |
All-trans-retinoic acid decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
20488242
SP1 affects OTUD1
| 2
SP1 activates OTUD1. 2 / 2
| 2
reach
"Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation."
34826170
reach
"Thus, our results demonstrated that melatonin induced apoptosis by stabilizing Bim via Sp1-mediated OTUD1 upregulation."
34826170
SMAD7 affects OTUD1
| 2
OTUD1 binds SMAD7. 2 / 2
| 2
sparser
"Moreover, Zhang et al. reported that OTUD1 binds with and stabilizes SMAD7 to repress the metastasis of breast cancer xref ."
35280681
sparser
"OTUD1 associates with SMAD7 and deubiquitinates SMAD7 in vitro."
29235476
SKP2 affects OTUD1
| 2
SKP2 binds YAP1 and OTUD1. 1 / 1
| 1
sparser
"K63-linked ubiquitination of YAP was upregulated in cells at low density (Fig.  xref ), which prompted us to examine whether cell density can influence the interaction of YAP with SKP2 or OTUD1."
29891922
SKP2 binds OTUD1. 1 / 1
| 1
sparser
"To assess whether the expression of SKP2 or OTUD1 is associated with clinical outcomes in breast cancer patients, we performed Kaplan–Meier (KM) plotter analysis of microarray datasets of human mammary tumors xref ."
29891922
OTUD1 affects production
| 2
OTUD1 inhibits production. 2 / 2
| 2
sparser
"As a consequence, OTUD1 inhibits MAVS/TRAF3/TRAF6 signalosome-mediated production of type I IFNs and proinflammatory cytokines during RNA virus infection ( xref )."
29734366
sparser
"In a screen of deubiquitinases expression cloning library [ xref , xref ], we found that the deubiquitinase OTUD1 could inhibit RNA virus-induced production of type I IFNs."
29734366
OTUD1 affects nicD
| 2
OTUD1 activates nicD. 2 / 2
| 2
reach
"OTUD1-driven NICD signaling promoted the differentiation and functions of Th1 and Th17 cells and amplified the cascade of aGVHD."
36574342
reach
"Activation of CD4+ T cells after allo-HSCT elevated the protein levels of OTUD1, which in turn interacted with the Notch2-ICD (NICD) to cleave the ubiquitin of NICD at the K1770 site, thereby inducing NICD protein accumulations in T cells."
36574342
OTUD1 affects immune response
| 2
OTUD1 inhibits immune response.
| 1
Mutated OTUD1 inhibits immune response. 1 / 1
| 1
reach
"Our data demonstrate that OTUD1 is involved in maintaining immune homeostasis and loss-of-function mutations of OTUD1 enhance the immune response and are associated with autoimmunity."
30100102
OTUD1 activates immune response.
| 1
OTUD1 activates immune response. 1 / 1
| 1
reach
"The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity."
33393230
reach
"We detect upregulated OTUD1 in the vascular endothelium of Ang II-challenged mice and show that OTUD1 deletion attenuates vascular remodeling, collagen deposition, and EndMT."
36579465
reach
"Finally, SMAD3 inhibition reverses OTUD1-promoted vascular remodeling."
36579465
OTUD1 affects VIM
| 1 1
OTUD1 decreases the amount of VIM.
| 1
Modified OTUD1 decreases the amount of VIM. 1 / 1
| 1
reach
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2, FN1, and VIM."
29235476
OTUD1 binds VIM.
| 1
VIM binds CDH1, CDH2, OTUD1, and FN1. 1 / 1
| 1
sparser
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2 , FN1 , and VIM (Fig.  xref )."
29235476
OTUD1 affects TRAF3, and TRAF6
| 2
TRAF3 binds TRAF6 and OTUD1. 2 / 2
| 2
sparser
"Therefore, we studied whether OTUD1 could interact with TRAF3 or TRAF6."
29734366
sparser
"Results showed that OTUD1 was also capable of interacting with both TRAF3 ( xref ) and TRAF6 ( xref )."
29734366
OTUD1 affects RLR
| 2
OTUD1 inhibits RLR. 2 / 2
| 2
reach
"Our study clearly demonstrates that the deubiquitinase OTUD1 negatively regulates RLR signaling."
29734366
reach
"Finally, the deubiquitinase OTUD1 potently inhibits RLR pathway by utilizing Smurf1-MAVS/TRAF3/TRAF6 signaling at the early stage of viral infection."
29734366
OTUD1 affects RIPK1
1 | 1
OTUD1 inhibits RIPK1.
| 1
OTUD1 inhibits RIPK1. 1 / 1
| 1
reach
"When treated with the DUB panel, OTUD1 substantially reduced HMW forms of RIP1, suggesting the prevalence of Lys63 linkages on RIP1."
23827681
OTUD1 binds RIPK1.
1 |
RIPK1 binds OTUD1. 1 / 1
1 |
biogrid
No evidence text available
23827681
OTUD1 affects Pathway
| 2
OTUD1 activates Pathway. 2 / 2
| 2
sparser
"OTUD1 Recruits the CUL4A‐DDB1 Complex to Promote MCL1 Degradation and Activate the Caspase‐Dependent Apoptosis Pathway."
33898171
sparser
"OTUD1 Activates the Caspase‐Independent Apoptosis Pathway."
33898171
OTUD1 affects NSCLC
| 2
OTUD1 inhibits NSCLC. 2 / 2
| 2
reach
"Our study revealed that OTUD1 suppresses NSCLC progression by mediating KLF4 stabilization, which suggests a potential gene target for the future treatment of NSCLC."
35098684
reach
"Overexpression of OTUD1 inhibited NSCLC cell progression and it was promoted by knockdown of OTUD1."
35098684
OTUD1 affects MDM2
| 1
OTUD1 increases the amount of MDM2. 1 / 2
| 1
reach
"We also found that wild-type OTUD1 upregulated p21 and Mdm2 expression but inactive OTUD1 mutant did not."
28216291
OTUD1 affects MAVS/TRAF3/TRAF6 proteins
| 2
OTUD1 inhibits MAVS/TRAF3/TRAF6 proteins.
| 1
OTUD1 inhibits MAVS/TRAF3/TRAF6 proteins. 1 / 1
| 1
reach
"Our data showed that OTUD1 deficiency in Otud1 -/- BMDMs blocked the downregulation of MAVS/TRAF3/TRAF6 proteins during VSV infection, when compared to Otud1 +/+ BMDMs (XREF_FIG), suggesting that OTUD1 is required for RNA virus induced downregulation of MAVS/TRAF3/TRAF6 proteins."
29734366
OTUD1 activates MAVS/TRAF3/TRAF6 proteins.
| 1
OTUD1 activates MAVS/TRAF3/TRAF6 proteins. 1 / 1
| 1
reach
"Importantly, OTUD1 contributes to RNA virus induced downregulation of MAVS/TRAF3/TRAF6 proteins."
29734366
OTUD1 affects Klk9
| 2
SMURF1 binds OTUD1 and Klk9. 1 / 1
| 1
sparser
"We found that SeV infection promoted interaction between OTUD1 and Smurf1 ( xref )."
29734366
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
OTUD1 affects KEAP1
| 1 1
KEAP1 binds OTUD1. 2 / 2
| 1 1
sparser
"Mass spectrometric analysis showed that OTUD1 binds KEAP1, and the N-terminal intrinsically disordered region of OTUD1, which contains an ETGE motif, is indispensable for the KEAP1-binding."
35941131
reach
"Mass spectrometric analysis showed that OTUD1 binds KEAP1, and the N-terminal intrinsically disordered region of OTUD1, which contains an ETGE motif, is indispensable for the KEAP1-binding."
35941131
OTUD1 affects IRF3
| 1 1
OTUD1 binds IRF3. 1 / 1
| 1
sparser
"OTUD1 interacts with IRF3 to remove the K63-linked poly-ubiquitin chains on IRF3 and to suppress the interferon activity."
32151092
OTUD1 binds IRF3 and K63. 1 / 1
| 1
reach
"As a deubiquitinase, OTUD1 directly interacts with transcription factor IRF3 and removes the K63 linked poly-ubiquitin chains on IRF3 Lysine 98, which inhibits IRF3 nuclear translocation and transcriptional activity."
30100102
OTUD1 affects Heart Failure
| 1 1
OTUD1 inhibits Heart Failure.
| 1
eidos
"OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes ."
37153745
OTUD1 activates Heart Failure.
| 1
OTUD1 activates Heart Failure. 1 / 1
| 1
reach
"OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes."
37153745
OTUD1 affects Flag
| 2
OTUD1 binds Flag. 2 / 2
| 2
sparser
"MS was performed as previously described. [ xref ] Briefly, Flag‐OTUD1 was transfected into 293T cells, and cell lysates were immunoprecipitated with anti‐Flag magnetic beads."
33898171
sparser
"GST‐tagged AIF was confirmed to be directly associated with Flag‐OTUD1, and vice versa (Figure  xref )."
33898171
OTUD1 affects FN1
| 1 1
OTUD1 decreases the amount of FN1.
| 1
Modified OTUD1 decreases the amount of FN1. 1 / 1
| 1
reach
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2, FN1, and VIM."
29235476
OTUD1 binds FN1.
| 1
VIM binds CDH1, CDH2, OTUD1, and FN1. 1 / 1
| 1
sparser
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2 , FN1 , and VIM (Fig.  xref )."
29235476
OTUD1 affects DCAF10
| 2
DCAF10 binds CUL4A, DDB1, and OTUD1. 1 / 1
| 1
sparser
"Interestingly, two molecules (DDB1 and DCAF10) in the MS data attracted our attention because DCAFs function as substrate receptors for the CUL4‐DDB1 ubiquitin ligase, [ xref ] which was identified as mediating the ubiquitination of MCL1 in a recent study. [ xref ] We next performed co‐IP assays and showed that CUL4A, DDB1, and DCAF10 associated with wild‐type OTUD1, but not OTUD1 C320A , in vivo (Figure  xref – xref )."
33898171
DCAF10 binds OTUD1. 1 / 1
| 1
sparser
"The results showed that only DCAF10 associated with OTUD1 in vitro (Figure S7A–C, Supporting Information)."
33898171
OTUD1 inhibits Carcinoma, Non-Small-Cell Lung. 2 / 2
| 1 1
reach
"The deubiquitinase OTUD1 inhibits non-small cell lung cancer progression by deubiquitinating and stabilizing KLF4."
35098684
eidos
"Our study revealed that OTUD1 suppresses NSCLC progression by mediating KLF4 stabilization , which suggests a potential gene target for the future treatment of NSCLC ."
35098684
OTUD1 affects CFH
| 2
OTUD1 ubiquitinates CFH.
| 1
OTUD1 ubiquitinates CFH. 1 / 1
| 1
reach
"These results indicated that the deubiquitinase OTUD1, which was upregulated by VE-822, inhibited the progression of LUAD in vitro and in vivo by deubiquitinating and stabilizing FHL1."
36929488
OTUD1 deubiquitinates CFH.
| 1
OTUD1 deubiquitinates CFH. 1 / 1
| 1
reach
"These results indicated that the deubiquitinase OTUD1, which was upregulated by VE-822, inhibited the progression of LUAD in vitro and in vivo by deubiquitinating and stabilizing FHL1."
36929488
OTUD1 affects CDH2
| 1 1
OTUD1 decreases the amount of CDH2.
| 1
Modified OTUD1 decreases the amount of CDH2. 1 / 1
| 1
reach
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2, FN1, and VIM."
29235476
OTUD1 binds CDH2.
| 1
VIM binds CDH1, CDH2, OTUD1, and FN1. 1 / 1
| 1
sparser
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2 , FN1 , and VIM (Fig.  xref )."
29235476
OTUD1 affects AHI1
| 1 1
AHI1 binds OTUD1. 2 / 2
| 1 1
sparser
"Next, we confirmed the interaction between AHI1 and OTUD1, as well as Tyk2, in both primary macrophages (Fig.  xref ) and A549 cells (Supplementary information, Fig. S xref a)."
35821088
reach
"Next, we confirmed the interaction between AHI1 and OTUD1, as well as Tyk2, in both primary macrophages (Fig. 4c) and A549 cells (Supplementary information, Fig. S5a)."
35821088
Klk9 affects OTUD1
| 2
SMURF1 binds OTUD1 and Klk9. 1 / 1
| 1
sparser
"We found that SeV infection promoted interaction between OTUD1 and Smurf1 ( xref )."
29734366
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
KEAP1 affects OTUD1
| 1 1
KEAP1 binds OTUD1. 2 / 2
| 1 1
sparser
"Mass spectrometric analysis showed that OTUD1 binds KEAP1, and the N-terminal intrinsically disordered region of OTUD1, which contains an ETGE motif, is indispensable for the KEAP1-binding."
35941131
reach
"Mass spectrometric analysis showed that OTUD1 binds KEAP1, and the N-terminal intrinsically disordered region of OTUD1, which contains an ETGE motif, is indispensable for the KEAP1-binding."
35941131
HRAS affects OTUD1
| 2
HRAS decreases the amount of OTUD1. 2 / 2
| 2
reach
"Similar as the BRCA1 and BRCA2 tumor suppressors, expression of OTUD1 was significantly suppressed by wild-type HRAS in p53 null MCF10A cells, but not in the control MCF10A cells (p53-wt), indicating that gain of oncogenic RAS together with loss of p53 tumor suppressor could lead to decreased OTUD1 function (GSE81593)."
29235476
reach
"Consistent with the notion that activation of HRAS inhibits OTUD1 expression in p53 mutant cells, we found that upon ectopic expression of constitutively active HRASV12, OTUD1 is downregulated in p53 mutant MDA-MB-231 (both the early passage and the bone-metastatic (BM) cell lines) but not in p53 wt MCF7 cells, TGF-beta and HRAS collaborate to promote EMT, invasion and cancer stem traits in breast cancer cells 36."
29235476
Flag affects OTUD1
| 2
OTUD1 binds Flag. 2 / 2
| 2
sparser
"MS was performed as previously described. [ xref ] Briefly, Flag‐OTUD1 was transfected into 293T cells, and cell lysates were immunoprecipitated with anti‐Flag magnetic beads."
33898171
sparser
"GST‐tagged AIF was confirmed to be directly associated with Flag‐OTUD1, and vice versa (Figure  xref )."
33898171
DDIT3 affects OTUD1
| 2
DDIT3 increases the amount of OTUD1. 2 / 2
| 2
reach
"Importantly, DDIT3 induced OTU deubiquitinase 1 (OTUD1) expression by activating the NF-kappaB signaling pathway, thus increasing intracellular Smurf1 protein levels to degrade MAVS and inhibit IFN-I production during BVDV infection."
33361422
reach
"DDIT3 promoted NF-kappaB-dependent OTU deubiquitinase 1 (OTUD1) expression."
33361422
DCAF10 affects OTUD1
| 2
DCAF10 binds CUL4A, DDB1, and OTUD1. 1 / 1
| 1
sparser
"Interestingly, two molecules (DDB1 and DCAF10) in the MS data attracted our attention because DCAFs function as substrate receptors for the CUL4‐DDB1 ubiquitin ligase, [ xref ] which was identified as mediating the ubiquitination of MCL1 in a recent study. [ xref ] We next performed co‐IP assays and showed that CUL4A, DDB1, and DCAF10 associated with wild‐type OTUD1, but not OTUD1 C320A , in vivo (Figure  xref – xref )."
33898171
DCAF10 binds OTUD1. 1 / 1
| 1
sparser
"The results showed that only DCAF10 associated with OTUD1 in vitro (Figure S7A–C, Supporting Information)."
33898171
CARD9 affects OTUD1
| 1 1
CARD9 binds OTUD1. 2 / 2
| 1 1
sparser
"OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-κB and MAPK pathway."
33789983
reach
"OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-kappaB and MAPK pathway."
33789983
AHI1 affects OTUD1
| 1 1
AHI1 binds OTUD1. 2 / 2
| 1 1
sparser
"Next, we confirmed the interaction between AHI1 and OTUD1, as well as Tyk2, in both primary macrophages (Fig.  xref ) and A549 cells (Supplementary information, Fig. S xref a)."
35821088
reach
"Next, we confirmed the interaction between AHI1 and OTUD1, as well as Tyk2, in both primary macrophages (Fig. 4c) and A549 cells (Supplementary information, Fig. S5a)."
35821088
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of OTUD1. 2 / 2
2 |
ctd
No evidence text available
21215274
ctd
No evidence text available
19770486
Zinc atom affects OTUD1
1 |
Zinc atom increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
18593933
Vinclozolin affects OTUD1
1 |
Vinclozolin decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
23555832
Urethane affects OTUD1
1 |
Urethane increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
28818685
Tris(1,3-dichloro-2-propyl)phosphate increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
26179874
Triclosan affects OTUD1
1 |
Triclosan increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
30510588
Sunitinib affects OTUD1
1 |
Sunitinib decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
31533062
Sulindac affects OTUD1
1 |
Sulindac increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
11906190
Schizandrin B affects OTUD1
1 |
Schizandrin B increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
31150632
Rotenone affects OTUD1
1 |
Rotenone decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
28374803
Polyubiquitin chains affects OTUD1
| 1
OTUD1 binds polyubiquitin chains. 1 / 1
| 1
reach
"OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-kappaB and MAPK pathway."
33789983
Pirinixic acid affects OTUD1
1 |
Pirinixic acid increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
18301758
Phenformin affects OTUD1
1 |
Phenformin decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
31324951
Ovarian tumor domain affects OTUD1
| 1
Ovarian tumor domain activates OTUD1. 1 / 1
| 1
eidos
"Moreover , the ovarian tumor domain allows the OTUD1 to separate IRF3 from the promoter region of the target gene and inhibits the normal production of interferon , while it does not affect the normal dimerization of IRF3 and translocate into the nucleus ."
34966378
Nickel sulfate affects OTUD1
1 |
Nickel sulfate increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
17374397
Naphthoquinone affects OTUD1
1 |
Naphthoquinone increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
23811387
Methyltestosterone increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
29191790
Methylparaben affects OTUD1
1 |
Methylparaben increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
31745603
Methylmercury chloride decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
28001369
Methyl methanesulfonate increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
23649840
Methotrexate affects OTUD1
1 |
Methotrexate decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
24449571
Metformin affects OTUD1
1 |
Metformin decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
31324951
Lipopolysaccharide activates OTUD1. 1 / 1
| 1
reach
"Consistent with the former investigations that IRF3 promoted inflammatory responses in LPS induced sepsis, Otud1 -/- mice were more susceptible to LPS stimulation."
32075857
Indole-3-methanol affects OTUD1
1 |
Indole-3-methanol increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
22129741
Hsa-miR-6761-5p affects OTUD1
1 |
Hsa-miR-6761-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-570-3p affects OTUD1
1 |
Hsa-miR-570-3p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-543 affects OTUD1
1 |
Hsa-miR-543 decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-539-5p affects OTUD1
1 |
Hsa-miR-539-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-506-3p affects OTUD1
1 |
Hsa-miR-506-3p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4329 affects OTUD1
1 |
Hsa-miR-4329 decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4262 affects OTUD1
1 |
Hsa-miR-4262 decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4251 affects OTUD1
1 |
Hsa-miR-4251 decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-421 affects OTUD1
1 |
Hsa-miR-421 decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-3910 affects OTUD1
1 |
Hsa-miR-3910 decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3714 affects OTUD1
1 |
Hsa-miR-3714 decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3613-3p affects OTUD1
1 |
Hsa-miR-3613-3p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-340-5p affects OTUD1
1 |
Hsa-miR-340-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-335-5p affects OTUD1
1 |
Hsa-miR-335-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Hsa-miR-320a affects OTUD1
1 |
Hsa-miR-320a decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-26b-5p affects OTUD1
1 |
Hsa-miR-26b-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-26a-5p affects OTUD1
1 |
Hsa-miR-26a-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-21-5p affects OTUD1
1 |
Hsa-miR-21-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-19a-3p affects OTUD1
1 |
Hsa-miR-19a-3p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-192-5p affects OTUD1
1 |
Hsa-miR-192-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-181d-5p affects OTUD1
1 |
Hsa-miR-181d-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-181c-5p affects OTUD1
1 |
Hsa-miR-181c-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-181b-5p affects OTUD1
1 |
Hsa-miR-181b-5p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-124-3p affects OTUD1
1 |
Hsa-miR-124-3p decreases the amount of OTUD1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Gentamycin affects OTUD1
1 |
Gentamycin decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
22061828
Formaldehyde affects OTUD1
1 |
Formaldehyde increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
23649840
Ethyl methanesulfonate increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
23649840
Ethanol affects OTUD1
1 |
Ethanol decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
31059573
Drug affects OTUD1
| 1
Drug activates OTUD1. 1 / 1
| 1
eidos
"Bioinformatics analyses and western blot were applied for investigating OTUD1 expression in lung cancer and the drug that upregulated OTUD1 ."
36929488
Dorsomorphin affects OTUD1
1 |
Dorsomorphin decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
27188386
Dibutyl phthalate affects OTUD1
1 |
Dibutyl phthalate increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
21266533
Coumestrol affects OTUD1
1 |
Coumestrol decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
19167446
Copper atom affects OTUD1
1 |
Copper atom increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
20971185
Carbon nanotube affects OTUD1
1 |
Carbon nanotube decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
25554681
Avobenzone affects OTUD1
1 |
Avobenzone increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
31016361
Acrylamide affects OTUD1
1 |
Acrylamide decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
28959563
YAP1 affects SKP2
| 1
SKP2 binds YAP1 and OTUD1. 1 / 1
| 1
sparser
"K63-linked ubiquitination of YAP was upregulated in cells at low density (Fig.  xref ), which prompted us to examine whether cell density can influence the interaction of YAP with SKP2 or OTUD1."
29891922
XPO1 affects OTUD1
1 |
XPO1 binds OTUD1. 1 / 1
1 |
biogrid
No evidence text available
26673895
VIM affects OTUD1
| 1
VIM binds CDH1, CDH2, OTUD1, and FN1. 1 / 1
| 1
sparser
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2 , FN1 , and VIM (Fig.  xref )."
29235476
VE-822 affects OTUD1
| 1
VE-822 activates OTUD1. 1 / 1
| 1
reach
"VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma."
36929488
USP11 affects OTUD1
1 |
USP11 binds OTUD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
UBC affects OTUD1
1 |
UBC binds OTUD1. 1 / 1
1 |
biogrid
No evidence text available
23827681
Tobacco Smoke Pollution increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
28065790
TRAF6 affects MAVS
| 1
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
TLR3 affects OTUD1
| 1
TLR3 increases the amount of OTUD1. 1 / 1
| 1
reach
"Interestingly, we found that Poly (I : C), a TLR3 signaling stimulator, also induced OTUD1 mRNA expression (XREF_SUPPLEMENTARY)."
29734366
TGFB affects OTUD1
| 1
TGFB activates OTUD1. 1 / 1
| 1
reach
"This latter effect is inhibited by the treatment of SB431542, a selective TbetaRI kinase inhibitor, suggesting that the autocrine TGF-beta is sufficient to promote EMT in OTUD1 depleted cells."
29235476
TAZ affects OTUD1
| 1
TAZ inhibits OTUD1. 1 / 1
| 1
reach
"In line with this, the transcription of the pluripotency factors NANOG, SOX2, OCT4, and TAZ were significantly elevated in OTUD1 depleted tumors and severely inhibited in tumors expressing wild-type OTUD1."
29235476
Soman affects OTUD1
1 |
Soman increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
19281266
SOX2 affects OTUD1
| 1
SOX2 inhibits OTUD1. 1 / 1
| 1
reach
"In line with this, the transcription of the pluripotency factors NANOG, SOX2, OCT4, and TAZ were significantly elevated in OTUD1 depleted tumors and severely inhibited in tumors expressing wild-type OTUD1."
29235476
SMURF1 affects Klk9
| 1
SMURF1 binds OTUD1 and Klk9. 1 / 1
| 1
sparser
"We found that SeV infection promoted interaction between OTUD1 and Smurf1 ( xref )."
29734366
SKP2 affects YAP1
| 1
SKP2 binds YAP1 and OTUD1. 1 / 1
| 1
sparser
"K63-linked ubiquitination of YAP was upregulated in cells at low density (Fig.  xref ), which prompted us to examine whether cell density can influence the interaction of YAP with SKP2 or OTUD1."
29891922
RIPK1 affects OTUD1
1 |
RIPK1 binds OTUD1. 1 / 1
1 |
biogrid
No evidence text available
23827681
RAD23B affects OTUD1
1 |
OTUD1 binds RAD23B. 1 / 1
1 |
biogrid
No evidence text available
19615732
RAD23A affects OTUD1
1 |
OTUD1 binds RAD23A. 1 / 1
1 |
biogrid
No evidence text available
19615732
POU5F1 affects OTUD1
| 1
POU5F1 inhibits OTUD1. 1 / 1
| 1
reach
"In line with this, the transcription of the pluripotency factors NANOG, SOX2, OCT4, and TAZ were significantly elevated in OTUD1 depleted tumors and severely inhibited in tumors expressing wild-type OTUD1."
29235476
PCI 5002 affects OTUD1
1 |
PCI 5002 increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
18593933
OTUD1 affects transport
| 1
OTUD1 activates transport. 1 / 1
| 1
reach
"The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity."
33393230
OTUD1 affects transferrin receptor protein
| 1
OTUD1 activates transferrin receptor protein. 1 / 1
| 1
eidos
"Mechanistically , OTUD1 promotes transferrin receptor protein 1 ( TFRC ) - mediated iron transportation through deubiquitinating and stabilizing IREB2 , leading to increased ROS generation and ferroptosis ."
33393230
OTUD1 affects sub
| 1
OTUD1 activates sub. 1 / 1
| 1
reach
"Similarly, cysteine-to-alanine substitutions in the active sites of Ubp8 and the OTU class DUB, OTUD1, also increase DUB affinity for polyubiquitin (Figs XREF_FIG and XREF_FIG A)."
30150323
OTUD1 affects signaling
| 1
OTUD1 inhibits signaling. 1 / 1
| 1
sparser
"We next investigated the molecular mechanism by which OTUD1 inhibits TGF-β/SMAD signaling."
29235476
OTUD1 affects sensitivity renal cancer cells TKIs
| 1
OTUD1 inhibits sensitivity renal cancer cells TKIs. 1 / 1
| 1
eidos
"Subsequently , we revealed that downregulation of OTUD1 contributes to the sensitivity of renal cancer cells to TKIs , and this effect was blocked by TNF / NF-kappa B inhibitors and AKT inhibitors ."
35280681
OTUD1 affects self-ubiquitination
| 1
OTUD1 inhibits self-ubiquitination. 1 / 1
| 1
eidos
"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1 , prevent its self-ubiquitination degradation , and upregulate its protein level ; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS , and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination ( possibly k63-linked ) and enzyme activity of Smurf1 ( Table 1 ) ( 47 , 49 ) ."
32536927
OTUD1 affects release molecular patterns
| 1
OTUD1 inhibits release molecular patterns. 1 / 1
| 1
eidos
"Moreover , the presence of OTUD1 promotes the release of damage-associated molecular patterns ( DAMPs ) , which in turn recruits the leukocytes and strengthens host immune response ."
33393230
OTUD1 affects recruitment NF-kappaB essential modulator
| 1
OTUD1 inhibits recruitment NF-kappaB essential modulator. 1 / 1
| 1
eidos
"Mechanistically , OTUD1 physically interacts with receptor-interacting serine / threonine-protein kinase 1 ( RIPK1 ) and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-kappaB essential modulator ( NEMO ) ."
34876703
OTUD1 activates reactive oxygen species. 1 / 1
| 1
reach
"OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways."
35941131
OTUD1 affects proteins involved muscle contraction
| 1
OTUD1 activates proteins involved muscle contraction. 1 / 1
| 1
eidos
"OTUD1 deficiency can destabilize the proteins involved in muscle contraction ."
| PMC
OTUD1 affects protein
| 1
OTUD1 activates protein. 1 / 1
| 1
eidos
"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1 , prevent its self-ubiquitination degradation , and upregulate its protein level ; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS , and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination ( possibly k63-linked ) and enzyme activity of Smurf1 ( Table 1 ) ( 47 , 49 ) ."
32536927
OTUD1 affects protein intracellular Smurf1
| 1
OTUD1 activates protein intracellular Smurf1. 1 / 1
| 1
eidos
"For example , OTUD1 upregulates the protein levels of intracellular Smurf1 by removing the K48-linked polyubiquitin chains of Smurf1 , and RNA virus infection promotes the binding of Smurf1 to MAVS , TRAF3 , and TRAF6 , which leads to ubiquitination-dependent degradation of the three proteins and subsequent potent inhibition of IFNs production ( 64 ) ."
34707613
OTUD1 affects proinflammatory cytokine
| 1
OTUD1 activates proinflammatory cytokine. 1 / 1
| 1
eidos
"OTUD1 deficiency impaired CARD9-mediated signaling and inhibited the proinflammatory cytokine production following fungal stimulation ."
33789983
OTUD1 affects polyubiquitination
| 1
OTUD1 inhibits polyubiquitination. 1 / 1
| 1
sparser
"However, specific protein substrates whose K63-linked polyubiquitination is inhibited by OTUD1 remain unknown."
29891922
OTUD1 affects polyubiquitin chains
| 1
OTUD1 binds polyubiquitin chains. 1 / 1
| 1
reach
"OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-kappaB and MAPK pathway."
33789983
OTUD1 affects pathway
| 1
OTUD1 activates pathway. 1 / 1
| 1
sparser
"To study the mechanism underlying the activation of the caspase‐independent apoptosis pathway by OTUD1, we transfected Flag‐tagged OTUD1 into 293T cells and performed an immunoprecipitation assay using anti‐Flag magnetic beads."
33898171
OTUD1 affects nuclear translocation transcriptional transcription IRF3
| 1
OTUD1 inhibits nuclear translocation transcriptional transcription IRF3. 1 / 1
| 1
eidos
"OTUD1 ( Ovarian Tumor Family Deubiquitinase 1 , FDR = 3.74 x 10-13 ) can inhibit nuclear translocation and transcriptional activity of the IFNgamma-activated transcription factor IRF3 ( Lu et al ., 2018 ) , and loss of function of OTUD1 is associated with auto-immune diseases mediated by interferons ( Lu et al ., 2018 ) ."
33013356
OTUD1 inhibits necroptotic process. 1 / 1
| 1
reach
"OTUD1 negatively regulates the canonical NF-κB activation, apoptosis, and necroptosis, whereas OTUD1 upregulates the interferon (IFN) antiviral pathway."
35941131
OTUD1 affects melatonin-induced Bim
| 1
OTUD1 activates melatonin-induced Bim. 1 / 1
| 1
eidos
"OTUD1 knockdown inhibited melatonin-induced Bim upregulation and apoptosis in cancer cells ."
34826170
OTUD1 affects localization
| 1
OTUD1 inhibits localization. 1 / 1
| 1
reach
"Based on the evidence from overexpression, knockdown, and CRISPR-Cas9-mediated knockout of SKP2 or OTUD1, we found that SKP2 promotes, while OTUD1 inhibits the nuclear localization, transcriptional activity, and growth-promoting function of YAP."
31225491
OTUD1 affects iron atom
| 1
OTUD1 activates iron atom. 1 / 1
| 1
reach
"The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity."
33393230
OTUD1 affects interferon-mediated disease128
| 1
OTUD1 inhibits interferon-mediated disease128. 1 / 1
| 1
eidos
"In experiments in vitro and in vivo in mice , OTUD1 repressed type I interferon-mediated disease128 ."
35523963
OTUD1 affects interferon IFN antiviral pathway
| 1
OTUD1 activates interferon IFN antiviral pathway. 1 / 1
| 1
eidos
"OTUD1 negatively regulates the canonical NF-kappaB activation , apoptosis , and necroptosis , whereas OTUD1 upregulates the interferon ( IFN ) antiviral pathway ."
35941131
OTUD1 affects function OTUD1
| 1
OTUD1 inhibits function OTUD1. 1 / 1
| 1
eidos
"OTUD1 ( Ovarian Tumor Family Deubiquitinase 1 , FDR = 3.74 x 10-13 ) can inhibit nuclear translocation and transcriptional activity of the IFNgamma-activated transcription factor IRF3 ( Lu et al ., 2018 ) , and loss of function of OTUD1 is associated with auto-immune diseases mediated by interferons ( Lu et al ., 2018 ) ."
33013356
OTUD1 affects enzymatic Aurora-A
| 1
OTUD1 activates enzymatic Aurora-A. 1 / 1
| 1
eidos
"Moreover , OTUD1 was not able to increase the enzymatic activity of Aurora-A as much as OTUD6A ."
33669244
OTUD1 affects disassociation IRF3 target
| 1
OTUD1 activates disassociation IRF3 target. 1 / 1
| 1
eidos
"Hence , OTUD1 cleaves the K6-linked ubiquitin chain and leads to the disassociation of IRF3 from the promoter region of target genes , thereby attenuating type I IFN induction ."
33511009
OTUD1 affects deubiquitination Aurora-A
| 1
OTUD1 activates deubiquitination Aurora-A. 1 / 1
| 1
eidos
"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A ( Figure 2a ) ."
33669244
OTUD1 inhibits cytokine production. 1 / 1
| 1
reach
"OTUD1 deficiency impaired CARD9 mediated signaling and inhibited the proinflammatory cytokine production following fungal stimulation."
33789983
OTUD1 affects creatine
| 1
OTUD1 activates creatine. 1 / 1
| 1
reach
"Among ubiquitin ligases, MURF1, a gene known to target creatine kinase and muscle contractile proteins, and OTUD1 coding for a deubiquitinase protease, were up-regulated in the LM of Met5 pigs."
34087692
OTUD1 affects cell growth
| 1
OTUD1 inhibits cell growth. 1 / 1
| 1
reach
"In this process, OTUD1 could remove the K63 linkage ubiquitination of YAP and negatively regulate transcriptional activity and cell growth."
32140262
OTUD1 activates cell differentiation. 1 / 1
| 1
reach
"OTUD1-driven NICD signaling promoted the differentiation and functions of Th1 and Th17 cells and amplified the cascade of aGVHD."
36574342
OTUD1 affects cell death
| 1
OTUD1 inhibits cell death. 1 / 1
| 1
reach
"The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein."
31467488
reach
"We detect upregulated OTUD1 in the vascular endothelium of Ang II-challenged mice and show that OTUD1 deletion attenuates vascular remodeling, collagen deposition, and EndMT."
36579465
OTUD1 affects cancer cells
| 1
OTUD1 activates cancer cells. 1 / 1
| 1
eidos
"OTUD1 knockdown inhibited melatonin-induced Bim upregulation and apoptosis in cancer cells ."
34826170
OTUD1 affects cancer cell growth
| 1
OTUD1 inhibits cancer cell growth. 1 / 1
| 1
eidos
"Then , we showed that OTUD1 inhibits cancer cell growth ."
35280681
OTUD1 affects activity
| 1
OTUD1 inhibits activity. 1 / 1
| 1
sparser
"OTUD1 retains YAP in the cytoplasm and inhibits its activity."
29891922
OTUD1 affects activation
| 1
OTUD1 inhibits activation. 1 / 1
| 1
sparser
"Results showed that knockdown of OTUD1 significantly enhanced activation of IFNβ promoter during SeV infection ( xref ), and overexpression of OTUD1 inhibited SeV-induced activation of IFNβ promoter ( xref )."
29734366
OTUD1 affects XPO1
1 |
XPO1 binds OTUD1. 1 / 1
1 |
biogrid
No evidence text available
26673895
OTUD1 affects Ubiquitination
| 1
eidos
"OTUD1 directly interacted with Bim and inhibited its ubiquitination ."
34826170
OTUD1 affects Ubiquitin
| 1
OTUD1 activates mutated Ubiquitin. 1 / 1
| 1
reach
"Next, we analyzed the deubiquitination types of Smurf1 mediated by OTUD1 using two ubiquitin mutants, Ub-R48K (all lysines in Ub are mutated to arginines except lysine 48 residue) and Ub-R63K (all lysines in Ub are mutated to arginines except lysine 63 residue)."
29734366
OTUD1 affects Ub-R63K
| 1
OTUD1 activates Ub-R63K. 1 / 1
| 1
reach
"Next, we analyzed the deubiquitination types of Smurf1 mediated by OTUD1 using two ubiquitin mutants, Ub-R48K (all lysines in Ub are mutated to arginines except lysine 48 residue) and Ub-R63K (all lysines in Ub are mutated to arginines except lysine 63 residue)."
29734366
OTUD1 affects USP11
1 |
USP11 binds OTUD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD1 affects UBC
1 |
UBC binds OTUD1. 1 / 1
1 |
biogrid
No evidence text available
23827681
OTUD1 affects Th1 Cells
| 1
OTUD1 activates Th1 Cells. 1 / 1
| 1
reach
"OTUD1-driven NICD signaling promoted the differentiation and functions of Th1 and Th17 cells and amplified the cascade of aGVHD."
36574342
OTUD1 affects TNF
| 1
OTUD1 inhibits TNF. 1 / 1
| 1
reach
"OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs."
35280681
OTUD1 affects TBK1
| 1
OTUD1 inhibits TBK1. 1 / 1
| 1
reach
"These data indicate that OTUD1 inhibits the IFNs antiviral response downstream of MAVS and upstream of TBK1."
29734366
OTUD1 affects Smurf1-mediated K48linked ubiquitination
| 1
OTUD1 activates Smurf1-mediated K48linked ubiquitination. 1 / 1
| 1
eidos
"Similarly , Smurf1-mediated K48linked ubiquitination is upregulated by OTUD1 67 ."
34782737
OTUD1 affects Smurf1-MAVS/TRAF3/TRAF6
| 1
OTUD1 inhibits Smurf1-MAVS/TRAF3/TRAF6. 1 / 1
| 1
reach
"Finally, the deubiquitinase OTUD1 potently inhibits RLR pathway by utilizing Smurf1-MAVS/TRAF3/TRAF6 signaling at the early stage of viral infection."
29734366
OTUD1 affects SMAD
| 1
OTUD1 inhibits SMAD. 1 / 1
| 1
reach
"We next investigated the molecular mechanism by which OTUD1 inhibits TGF-beta and SMAD signaling."
29235476
OTUD1 affects SKP2, and YAP1
| 1
SKP2 binds YAP1 and OTUD1. 1 / 1
| 1
sparser
"K63-linked ubiquitination of YAP was upregulated in cells at low density (Fig.  xref ), which prompted us to examine whether cell density can influence the interaction of YAP with SKP2 or OTUD1."
29891922
OTUD1 affects SCF SKP2
| 1
OTUD1 inhibits SCF SKP2. 1 / 1
| 1
reach
"Here, we report that YAP is subject to non proteolytic, K63 linked polyubiquitination by the SCF SKP2 E3 ligase complex (SKP2), which is reversed by the deubiquitinase OTUD1."
29891922
OTUD1 affects RIG-I-like receptors
| 1
OTUD1 inhibits RIG-I-like receptors. 1 / 1
| 1
reach
"Under inflammatory conditions, inducible OTUD1 acts as an immune checkpoint and blocks RIG-I-like receptors signaling."
30100102
OTUD1 affects RAS
| 1
OTUD1 activates RAS. 1 / 1
| 1
reach
"Depletion of endogenous OTUD1 potentiated the capacity of RAS transformed MCF10A cells to form tumor organoids in 3D Matrigel but did not inhibit tumor cell survival and proliferation under standard 2D culture conditions."
29235476
OTUD1 affects RAD23B
1 |
OTUD1 binds RAD23B. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD1 affects RAD23A
1 |
OTUD1 binds RAD23A. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD1 affects PRDX4
| 1
OTUD1 deubiquitinates PRDX4. 1 / 1
| 1
reach
"Mechanistically, OTUD1 deubiquitinates peroxiredoxin 4 (PRDX4), protecting it from endoplasmic reticulum (ER)-associated degradation."
36357400
OTUD1 affects PI3K
| 1
OTUD1 inhibits PI3K. 1 / 1
| 1
reach
"OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs."
35280681
OTUD1 affects PARP1
| 1
OTUD1 activates PARP1. 1 / 1
| 1
reach
"Next, we confirmed that OTUD1 overexpression increased the cleavage of caspase-3 and PARP and subsequently increased apoptosis."
28216291
OTUD1 affects OTUD6A
| 1
OTUD1 activates OTUD6A. 1 / 1
| 1
reach
"Moreover, OTUD1 was not able to increase the enzymatic activity of Aurora-A as much as OTUD6A."
33669244
OTUD1 affects NFkappaB
| 1
OTUD1 inhibits NFkappaB. 1 / 1
| 1
reach
"OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs."
35280681
OTUD1 affects MCF10A cells expressing RAS metastasis breast cancer cells mice
| 1
OTUD1 inhibits MCF10A cells expressing RAS metastasis breast cancer cells mice. 1 / 1
| 1
eidos
"Moreover , OTUD1 suppresses TGF-beta signaling and EMT in MCF10A cells expressing RAS and metastasis of breast cancer cells in mice , respectively , presumably through deubiquitylating SMAD7 thus enabling SMURF2 binding and subsequent TGFR turnover43 ."
30696809
OTUD1 affects MAVS/TRAF3/TRAF6 signalosome
| 1
OTUD1 activates MAVS/TRAF3/TRAF6 signalosome. 1 / 1
| 1
reach
"Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome."
29734366
OTUD1 affects MAVS/TRAF3/TRAF6 signalosome proteins
| 1
OTUD1 inhibits MAVS/TRAF3/TRAF6 signalosome proteins. 1 / 1
| 1
reach
"Taken together, these data suggest that OTUD1 is responsible for downregulation of both MAVS/TRAF3/TRAF6 signalosome proteins and subsequent production of IFNbeta mRNA at the early stage of RNA virus infection."
29734366
OTUD1 affects MAVS/TRAF3/TRAF6 protein
| 1
OTUD1 decreases the amount of MAVS/TRAF3/TRAF6 protein. 1 / 1
| 1
reach
"Given that OTUD1 downregulated MAVS/TRAF3/TRAF6 protein levels, we next questioned whether OTUD1 could inhibit MAVS/TRAF3/TRAF6 signalosome mediated IFNs production and antiviral activity."
29734366
OTUD1 affects Lys63-polyUb
| 1
OTUD1 inhibits Lys63-polyUb. 1 / 1
| 1
reach
"OTUD1 reduced Lys63-polyUb to monoUb (XREF_FIG C, 7D, XREF_FIG F, and S6G), and OTUB1 generated monoUb from E6AP assembled Lys48-polyUb (XREF_FIG E and S6H)."
23827681
OTUD1 affects KLF4
| 1
OTUD1 deubiquitinates KLF4. 1 / 1
| 1
reach
"OTUD1 was positively correlated with KLF4 and stabilized KLF4 at protein level by deubiquitinating KLF4."
35098684
OTUD1 affects K63
| 1
OTUD1 binds IRF3 and K63. 1 / 1
| 1
reach
"As a deubiquitinase, OTUD1 directly interacts with transcription factor IRF3 and removes the K63 linked poly-ubiquitin chains on IRF3 Lysine 98, which inhibits IRF3 nuclear translocation and transcriptional activity."
30100102
OTUD1 affects K6-linked ubiquitination
| 1
OTUD1 inhibits K6-linked ubiquitination. 1 / 1
| 1
eidos
"] Moreover , a recent study reported OTUD1 also reverses K6-linked ubiquitination from IRF3 upon viral infection ."
33511009
OTUD1 affects K48-linked polyubiquitination Tyk2
| 1
OTUD1 inhibits K48-linked polyubiquitination Tyk2. 1 / 1
| 1
eidos
"OTUD1 inhibits K48-linked polyubiquitination of Tyk2 dependently on AHI1 ."
35821088
OTUD1 affects ISRE promoter
| 1
OTUD1 inhibits ISRE promoter. 1 / 1
| 1
reach
"And exogenous expression of OTUD1 lowered SeV induced ISRE promoter activity (XREF_SUPPLEMENTARY)."
29734366
OTUD1 affects IL6
| 1
OTUD1 activates IL6. 1 / 1
| 1
reach
"At day 3 after VSV infection, Otud1 -/- mice produced much higher expression of IFNbeta and IL-6 mRNAs (XREF_FIG), and had much lower viral RNAs (XREF_FIG) in their lung tissue than did Otud1 +/+ mice."
29734366
OTUD1 affects IFNs
| 1
OTUD1 inhibits IFNs. 1 / 1
| 1
reach
"These data indicate that OTUD1 inhibits the IFNs antiviral response downstream of MAVS and upstream of TBK1."
29734366
OTUD1 affects IFN-I
| 1
OTUD1 inhibits IFN-I. 1 / 1
| 1
reach
"Importantly, DDIT3 induced OTU deubiquitinase 1 (OTUD1) expression by activating the NF-kappaB signaling pathway, thus increasing intracellular Smurf1 protein levels to degrade MAVS and inhibit IFN-I production during BVDV infection."
33361422
OTUD1 affects HRAS
| 1
OTUD1 activates HRAS. 1 / 1
| 1
reach
"In line with this, depletion of OTUD1 enhanced the effect of HRAS in MCF10A cells."
29235476
OTUD1 affects FLNC
1 |
OTUD1 binds FLNC. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD1 affects FLNB
1 |
OTUD1 binds FLNB. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD1 affects FLNA
1 |
OTUD1 binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD1 affects ERBB2
| 1
OTUD1 binds ERBB2. 1 / 1
| 1
sparser
"Furthermore, higher OTUD1 expression was significantly associated with low recurrence-free survival of HER2 + non-luminal subtype of breast cancer patients and EMT subtype of cervical cancer patients (Fig.  xref c, d)."
31467488
OTUD1 affects E3_Ub_ligase
| 1
OTUD1 inhibits E3_Ub_ligase. 1 / 1
| 1
reach
"Here, we report that YAP is subject to non proteolytic, K63 linked polyubiquitination by the SCF SKP2 E3 ligase complex (SKP2), which is reversed by the deubiquitinase OTUD1."
29891922
OTUD1 affects E3 ubiquitin ligase Smurf1
| 1
OTUD1 activates E3 ubiquitin ligase Smurf1. 1 / 1
| 1
eidos
"Furthermore , OTUD1 induced upregulation of the E3 ubiquitin ligase Smurf1 by deubiquitinating Smurf1 , and Smurf1 degraded MAVS in MDBK cells in a ubiquitination-dependent manner , ultimately inhibiting IFN-I production ."
33361422
OTUD1 affects DDX58
| 1
Modified OTUD1 increases the amount of DDX58. 1 / 1
| 1
reach
"Our data showed that OTUD1 overexpression had no obvious effects on IRF3 and TBK1 protein levels, and increased RIG-I protein levels to some extent (XREF_FIG)."
29734366
OTUD1 affects DDB1
| 1
DCAF10 binds CUL4A, DDB1, and OTUD1. 1 / 1
| 1
sparser
"Interestingly, two molecules (DDB1 and DCAF10) in the MS data attracted our attention because DCAFs function as substrate receptors for the CUL4‐DDB1 ubiquitin ligase, [ xref ] which was identified as mediating the ubiquitination of MCL1 in a recent study. [ xref ] We next performed co‐IP assays and showed that CUL4A, DDB1, and DCAF10 associated with wild‐type OTUD1, but not OTUD1 C320A , in vivo (Figure  xref – xref )."
33898171
OTUD1 affects Collagen
| 1
OTUD1 activates Collagen. 1 / 1
| 1
reach
"We detect upregulated OTUD1 in the vascular endothelium of Ang II-challenged mice and show that OTUD1 deletion attenuates vascular remodeling, collagen deposition, and EndMT."
36579465
OTUD1 affects ChFP
| 1
OTUD1 activates ChFP. 1 / 1
| 1
reach
"OTUB2, OTUD3, USP10 and UCHL1 expression did not alter the ChFP:GFP ratio of the control reporter while OTUD1 and USP21 only modestly elevated the ChFP:GFP ratio indicating that the identified Dubs specifically alter the ability of ribosomes to progress through a poly(A)-induced ribosomal stall (Figure 3B)."
32011234
OTUD1 affects Cell Survival
| 1
reach
"Depletion of endogenous OTUD1 potentiated the capacity of RAS transformed MCF10A cells to form tumor organoids in 3D Matrigel but did not inhibit tumor cell survival and proliferation under standard 2D culture conditions."
29235476
OTUD1 affects Caspase-Independent Caspase-Dependent Apoptosis
| 1
OTUD1 activates Caspase-Independent Caspase-Dependent Apoptosis. 1 / 1
| 1
eidos
"OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation ."
33898171
OTUD1 affects CUL4A
| 1
DCAF10 binds CUL4A, DDB1, and OTUD1. 1 / 1
| 1
sparser
"Interestingly, two molecules (DDB1 and DCAF10) in the MS data attracted our attention because DCAFs function as substrate receptors for the CUL4‐DDB1 ubiquitin ligase, [ xref ] which was identified as mediating the ubiquitination of MCL1 in a recent study. [ xref ] We next performed co‐IP assays and showed that CUL4A, DDB1, and DCAF10 associated with wild‐type OTUD1, but not OTUD1 C320A , in vivo (Figure  xref – xref )."
33898171
OTUD1 affects CDKN1A
| 1
OTUD1 increases the amount of CDKN1A. 1 / 1
| 1
reach
"We also found that wild-type OTUD1 upregulated p21 and Mdm2 expression but inactive OTUD1 mutant did not."
28216291
OTUD1 affects CDH1
| 1
VIM binds CDH1, CDH2, OTUD1, and FN1. 1 / 1
| 1
sparser
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2 , FN1 , and VIM (Fig.  xref )."
29235476
OTUD1 affects CASP3
| 1
OTUD1 activates CASP3. 1 / 1
| 1
reach
"Next, we confirmed that OTUD1 overexpression increased the cleavage of caspase-3 and PARP and subsequently increased apoptosis."
28216291
OTUD1 affects BRCA1
| 1
OTUD1 activates BRCA1. 1 / 1
| 1
reach
"Intriguingly, we observed that the 70 core targets of tumor suppressor Breast Cancer 1 (BRCA1) are all significantly enriched in OTUD1-high patients, strongly indicating that OTUD1 could support BRCA1 function."
29235476
OTUD1 affects ART4
| 1
OTUD1 leads to the deubiquitination of ART4. 1 / 1
| 1
reach
"The level of Art4-OTUD1 fusion in ubp2Delta ubp15Delta cells, however, was nearly identical to that in WT cells (XREF_FIG, lanes 5 and 6, and C), suggesting that OTUD1 efficiently prevents Art4 hype-r-ubiquitination."
28298493
OTUD1 affects AKT NF-kappa B pathways renal cancer cells
| 1
OTUD1 inhibits AKT NF-kappa B pathways renal cancer cells. 1 / 1
| 1
eidos
"Moreover , analysis of OTUD1 RNA-seq data indicated that OTUD1 inhibition triggers the AKT and NF-kappa B pathways in renal cancer cells ."
35280681
OTUD1 affects AHI1-mediated Tyk2
| 1
OTUD1 activates AHI1-mediated Tyk2. 1 / 1
| 1
eidos
"Importantly , OTUD1 knockdown inhibited the AHI1-mediated upregulation of Tyk2 levels ( Fig. 4e ) , suggesting that OTUD1 is essential for the AHI1-mediated regulation of Tyk2 protein levels ."
35821088
OTUD1 affects 4T1
| 1
OTUD1 inhibits 4T1. 1 / 1
| 1
reach
"qRT-PCR analysis indicated upregulation of cancer stem cell markers and EMT genes in OTUD1 depleted 4T1 lung-metastatic nodules when compared with control group, again suggesting that OTUD1 functions to oppose cancer stemness and EMT related gene expression programs."
29235476
OTUD1 activates 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexenyl]methyl]-1-piperazinyl]-N-[4-[[(2R)-4-(4-morpholinyl)-1-(phenylthio)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide. 1 / 1
| 1
reach
"Knockdown of OTUD1 increases the sensitivity of tumour cells to the BH3-mimetic inhibitor ABT-263, while overexpression of OTUD1 increases tumour cell tolerance of ABT-263."
31467488
NSC 689534 affects OTUD1
1 |
NSC 689534 increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
20971185
NFkappaB affects OTUD1
| 1
NFkappaB activates OTUD1. 1 / 1
| 1
reach
"Using a NF-kappaB inhibitor PDTC, we found that VSV induced upregulation of OTUD1 mRNA was significantly inhibited by pretreatment of cells with the NF-kappaB inhibitor (XREF_FIG), suggesting that NF-kappaB signaling contributes to RNA virus induced upregulation of OTUD1 mRNA."
29734366
NANOG affects OTUD1
| 1
NANOG inhibits OTUD1. 1 / 1
| 1
reach
"In line with this, the transcription of the pluripotency factors NANOG, SOX2, OCT4, and TAZ were significantly elevated in OTUD1 depleted tumors and severely inhibited in tumors expressing wild-type OTUD1."
29235476
N-nitrosodiethylamine increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
22129741
MAVS affects TRAF6
| 1
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
Klk9 affects SMURF1
| 1
SMURF1 binds OTUD1 and Klk9. 1 / 1
| 1
sparser
"We found that SeV infection promoted interaction between OTUD1 and Smurf1 ( xref )."
29734366
Klk9 affects MAVS, OTUD1, TRAF3, and TRAF6
| 1
TRAF3 binds TRAF6, OTUD1, MAVS, and Klk9. 1 / 1
| 1
sparser
"Interestingly, we did not observe obvious co-localization between OTUD1 and the mitochondria during SeV infection ( xref ), which is also consistent with the observation that OTUD1 does not interact with MAVS, TRAF3, or TRAF6 in cells infected with SeV ( xref )."
29734366
KLF4 affects OTUD1
| 1
KLF4 inhibits OTUD1. 1 / 1
| 1
reach
"Overexpressing KLF4 dramatically eliminated the effects of OTUD1 on the development of NSCLC cells."
35098684
K63 affects OTUD1
| 1
OTUD1 binds IRF3 and K63. 1 / 1
| 1
reach
"As a deubiquitinase, OTUD1 directly interacts with transcription factor IRF3 and removes the K63 linked poly-ubiquitin chains on IRF3 Lysine 98, which inhibits IRF3 nuclear translocation and transcriptional activity."
30100102
Grape Seed Proanthocyanidins increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
24763279
GSK-J4 affects OTUD1
1 |
GSK-J4 increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
29301935
FN1 affects VIM
| 1
VIM binds CDH1, CDH2, OTUD1, and FN1. 1 / 1
| 1
sparser
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2 , FN1 , and VIM (Fig.  xref )."
29235476
FLNC affects OTUD1
1 |
OTUD1 binds FLNC. 1 / 1
1 |
biogrid
No evidence text available
19615732
FLNB affects OTUD1
1 |
OTUD1 binds FLNB. 1 / 1
1 |
biogrid
No evidence text available
19615732
FLNA affects OTUD1
1 |
OTUD1 binds FLNA. 1 / 1
1 |
biogrid
No evidence text available
19615732
Enterolactone affects OTUD1
1 |
Enterolactone decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
19167446
ERBB2 affects OTUD1
| 1
OTUD1 binds ERBB2. 1 / 1
| 1
sparser
"Furthermore, higher OTUD1 expression was significantly associated with low recurrence-free survival of HER2 + non-luminal subtype of breast cancer patients and EMT subtype of cervical cancer patients (Fig.  xref c, d)."
31467488
Drugs, Chinese Herbal increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
23811387
Dietary Fats affects OTUD1
1 |
Dietary Fats increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
25016146
DDB1 affects OTUD1
| 1
DCAF10 binds CUL4A, DDB1, and OTUD1. 1 / 1
| 1
sparser
"Interestingly, two molecules (DDB1 and DCAF10) in the MS data attracted our attention because DCAFs function as substrate receptors for the CUL4‐DDB1 ubiquitin ligase, [ xref ] which was identified as mediating the ubiquitination of MCL1 in a recent study. [ xref ] We next performed co‐IP assays and showed that CUL4A, DDB1, and DCAF10 associated with wild‐type OTUD1, but not OTUD1 C320A , in vivo (Figure  xref – xref )."
33898171
D-glucopyranose affects OTUD1
1 |
D-glucopyranose increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
22634610
CUL4A affects OTUD1
| 1
DCAF10 binds CUL4A, DDB1, and OTUD1. 1 / 1
| 1
sparser
"Interestingly, two molecules (DDB1 and DCAF10) in the MS data attracted our attention because DCAFs function as substrate receptors for the CUL4‐DDB1 ubiquitin ligase, [ xref ] which was identified as mediating the ubiquitination of MCL1 in a recent study. [ xref ] We next performed co‐IP assays and showed that CUL4A, DDB1, and DCAF10 associated with wild‐type OTUD1, but not OTUD1 C320A , in vivo (Figure  xref – xref )."
33898171
CDH2 affects VIM
| 1
VIM binds CDH1, CDH2, OTUD1, and FN1. 1 / 1
| 1
sparser
"As expected, OTUD1 overexpression was associated with an increased expression level of the epithelial maker CDH1 and decreased expression levels of the mesenchymal markers CDH2 , FN1 , and VIM (Fig.  xref )."
29235476
BCL2L11 affects OTUD1
| 1
OTUD1 binds BCL2L11. 1 / 1
| 1
sparser
"OTUD1 directly interacted with Bim and inhibited its ubiquitination."
34826170
Aurora-A affects OTUD1
| 1
OTUD1 binds Aurora-A. 1 / 1
| 1
reach
"OTUD1, one of the final candidate DUBs for Aurora-A, bound to and deubiquitinated Aurora-A but its interaction with endogenous Aurora-A was much weaker than OTUD6A."
33669244
Air Pollutants affects OTUD1
1 |
Air Pollutants decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
21757418
AKT affects OTUD1
| 1
AKT binds OTUD1. 1 / 1
| 1
sparser
"Meanwhile, we also found that AKT did not bind with OTUD1 in 786-O cells ( xref A)."
35280681
6-propyl-2-thiouracil increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
24780913
ctd
No evidence text available
17374397
2-hydroxypropanoic acid increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
30851411
2,3,7,8-Tetrachlorodibenzofuran decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
32109520
17beta-estradiol affects OTUD1
1 |
17beta-estradiol increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
26496021
1-chloro-2,4-dinitrobenzene increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
17374397
1,2-dichloroethane decreases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
28960355
(+)-catechin affects OTUD1
1 |
(+)-catechin increases the amount of OTUD1. 1 / 1
1 |
ctd
No evidence text available
24763279