IndraLab

Statements

OTUD1 inhibits EAF2. 5 / 5
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"These results suggest that OTUD1 reduces the manifestation of cancer stem cell traits."
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"Combined, the in vitro and in vivo evidence in this study elucidates critical functions of OTUD1 in the termination of TGF-beta and SMAD-induced metastatic activation, indicating that OTUD1 restricts the EMT and cancer stem cell traits during metastasis."
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"OTUD1 inhibits cancer stem cell traits."
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"OTUD1 inhibits cancer stem cell traits."
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"From our screen, we have identified that loss of OTUD1 enables breast cancer cells to undergo EMT and gain cancer stem cell traits thereby driving metastatic spread to distant organs, such as bone and lung."
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