IndraLab
Statements
eidos
"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1 , prevent its self-ubiquitination degradation , and upregulate its protein level ; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS , and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination ( possibly k63-linked ) and enzyme activity of Smurf1 ( Table 1 ) ( 47 , 49 ) ."