IndraLab
Statements
USP24 is modified
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USP24 is phosphorylated.
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rlimsp
"Phosphorylation of USP24 at these three residues was increased during mitosis (Figures 7E and F). Moreover, cdc20 could also interact with USP24 when these residues were phosphorylated, implying that the decrease in USP24 during mitosis might be important for cell cycle progression and cancer cell proliferation (Figure 7G)."
rlimsp
"Our previous liquid chromatography–tandem mass spectrometry (LC/MS/MS) studies probed several phosphorylation residues within USP24 (Supplementary Table 1). The phosphorylation residues were mutated individually; then, we investigated the expression of USP24-wt and its mutants (Figures 7B and C; Supplementary Figure 5B)."
rlimsp
"Our previous liquid chromatography–tandem mass spectrometry (LC/MS/MS) studies probed several phosphorylation residues within USP24 (Supplementary Table 1). The phosphorylation residues were mutated individually; then, we investigated the expression of USP24-wt and its mutants (Figures 7B and C; Supplementary Figure 5B). Three mutated residues and triple mutant S3A increased the USP24 level, suggesting that USP24 phosphorylation might be the reason for the decreased USP24 expression during mitosis and tumorigenesis. Mutations at these residues increased the USP24 half-life during mitosis, suggesting that USP24 phosphorylation during mitosis decreased USP24 expression (Figure 7D). Antibodies that recognized these phosphorylation residues were produced to study USP24 phosphorylation."
USP24 is ubiquitinated.
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3
reach
"The data indicated that inhibition of autophagy decreased the cell entry from G2/M (Fig. 4D(b)), and increased chromosome separation defects, micronuclei and segregation defects (Fig. 4E), indicating that autophagic induction during mitosis could maintain genomic stability.Next, the effect of targeting USP24-induced autophagy on chemotherapy- and targeted therapy-induced drug-resistant lung cancer cells was studied (Fig. 4F and Supplementary Fig. 3)."
reach
"Gefitinib and USP24-i cocktail treatment significantly induced cell death but abolished this effect by inhibiting autophagy with Baf-A1 or CQ treatment, suggesting that targeting USP24-induced autophagy is essential for the effect of USP24-i on blocking drug resistance acquired by targeted therapy."
reach
"To examine if USP24 can target ubiquitinated DDB2 in vitro, we treated HeLa cells expressing Hig tagged DDB2 with MG132, a proteosome inhibitor, XREF_BIBR for 1 h and exposed HeLa cells to UVC (10 J/m 2) to stimulate DDB2 uniquitination for another hour, Ni-NTA beads were then used to pulldown modified His DDB2."
reach
"In cancer cells, USP24 increased p300 and beta-TrCP, thus increasing the acetylation of histone H3 and the degradation of DNMT1 and IkappaB, resulting in the recruitment of histone H3 acetylation to the promoter region of IL-6, the reduction of DNA methylation, and the promotion of NF-kappaB nuclear translocation, thereby facilitating IL-6 expression."
"In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its substrates in samples from clinical lung cancer patients. |Knockdown of USP24 decreases Bax and p300 levels"
"In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its substrates in samples from clinical lung cancer patients. |Knockdown of USP24 decreases Bax and p300 levels"
sparser
"For example, BUB1 kinase drives bladder cancer progression and proliferation by regulating STAT3 transcription (Jiang et al. xref ); in bladder cancer, USP24-GSDMB complex formation stimulates cell proliferation via STAT3-dependent mechanisms (He et al. xref ); ROC1 gives rise to bladder cancer malignancy via orchestrating NF-κB signaling activation (Wu et al. xref ); Mechanistic studies reveal that secretory granule protein II facilitates bladder cancer advancement by concurrently activating both MAPK and NF-κB pathways (Zhou et al. xref )."
reach
"There areseveral possible reasons for this : first, different DUBs might regulate the p53pathway in response to different cellu-lar stresses; second, different DUBsmight work in different cellular com-partments; and third, since p53 is suchan important protein that is ubiquiti nated by many different E3 ligases, dif-ferent DUBs may be required tocounteract p53 ubiquitination of dif-ferent ubiquitin linkage topologies.Indeed, it is known that DUBs havedifferent types of substrate cleavageactivities -- some generate free ubiqui-tin from linear substrate, some removeubiquitin from post-translationallymodified protein, and others edit polyubiquitin chains.10 A survey of the Catalog Of SomaticMutations In Cancer (COSMIC) data-base shows that USP24 is frequently mutated in various human cancers.6 Since p53 is a well-known tumor sup-pressor that regulates cell proliferationand USP24 potentiates p53 function byFigure 1."
reach
"Yu et al reported that ubiquitinase RNF126 affects the TME and promotes nasopharyngeal carcinoma progression through the regulation of PTEN ubiquitination.15 Wang et al discovered that an overexpression of USP24 in M2 macrophages can promote IL-6 transcription and tumour malignancy."
reach
"In addition to the p300 stabilization induced by USP24 in cancer cells to regulate IL-6 expression through increased histone H3 acetylation, USP24 also reduces DNA methylation in the promoter region of IL-6 in lung cancer cells, but not in M2 macrophages, to increase IL-6 transcription by decreasing DNMT1 protein stability."
reach
"After analyzing the five CpG sites upstream of the transcription start site, we found that the methylation status of a CpG site located at -123 was increased in A549 cells but not in M2 macrophages after USP24 knockdown, indicating that a decrease in IL-6 methylation induced by USP24 in A549 cells, but not in M2 macrophages, increases IL-6 mRNA levels."
sparser
"After analyzing the five CpG sites upstream of the transcription start site, we found that the methylation status of a CpG site located at −123 was increased in A549 cells but not in M2 macrophages after USP24 knockdown, indicating that a decrease in IL-6 methylation induced by USP24 in A549 cells, but not in M2 macrophages, increases IL-6 mRNA levels."
"In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its substrates in samples from clinical lung cancer patients. |Knockdown of USP24 decreases Bax and p300 levels"
"In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its substrates in samples from clinical lung cancer patients. |Knockdown of USP24 decreases Bax and p300 levels"
sparser
"Additionally, cellular double immunofluorescence assay provided morphological evidence of the interaction between USP24 and Beclin1 protein (Fig. xref and Supplementary Fig. xref ) and the colocalization coefficients increased after USP24 overexpression (Fig. xref and Supplementary Fig. xref )."
WP1130 affects USP24
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WP1130 inhibits USP24.
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reach
"The reason we were unable to detect other DUBs that WP1130 is known to target might be due to the use of USP18 overexpressing lysates (as we observed WP1130 competitively blocks the labeling of USP9X and USP24 in HEK293T cell lysates, data not shown) and the reversible nature of modification by WP1130."
WP1130 binds USP24.
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WP1130 activates USP24.
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WP1130 decreases the amount of USP24.
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reach
"Owing to the absence of structural information on the interaction between USP24 and YAP1, we generated a complex structural model of the interaction between USP24 and YAP1 by using the AlphaFold3 server [36], which provided a structural view to understand the interactions between USP24 and YAP1."
sparser
"Owing to the absence of structural information on the interaction between USP24 and YAP1, we generated a complex structural model of the interaction between USP24 and YAP1 by using the AlphaFold3 server [ xref ], which provided a structural view to understand the interactions between USP24 and YAP1."
reach
"Interestingly, qRT-PCR analysis results further revealed that the downregulation of USP24 expression in HCC cells lowered the mRNA expression levels of YAP1 targeted genes, including CTGF (~ 50%; P < 0.05) and CYR61 (~ 50%; P < 0.05), without affecting the mRNA level of YAP1 (Fig. 1E), suggesting that USP24 might regulate the expression of YAP1 at the post-translational level."
USP24 affects cell population proliferation
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USP24 inhibits cell population proliferation.
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USP24 activates cell population proliferation.
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USP24 activates cell population proliferation. 6 / 6
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USP24 bound to GSDMB activates cell population proliferation. 1 / 1
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sparser
"Additionally, cellular double immunofluorescence assay provided morphological evidence of the interaction between USP24 and Beclin1 protein (Fig. xref and Supplementary Fig. xref ) and the colocalization coefficients increased after USP24 overexpression (Fig. xref and Supplementary Fig. xref )."
sparser
"For example, BUB1 kinase drives bladder cancer progression and proliferation by regulating STAT3 transcription (Jiang et al. xref ); in bladder cancer, USP24-GSDMB complex formation stimulates cell proliferation via STAT3-dependent mechanisms (He et al. xref ); ROC1 gives rise to bladder cancer malignancy via orchestrating NF-κB signaling activation (Wu et al. xref ); Mechanistic studies reveal that secretory granule protein II facilitates bladder cancer advancement by concurrently activating both MAPK and NF-κB pathways (Zhou et al. xref )."
reach
"In summary, targeting USP24 by USP24-i inhibits E2F4, thereby increasing E2F1 expression, and subsequently increasing ULK1 and LC3 expression, resulting in autophagy in interphase.In previous studies, we showed that USP24 is downregulated during mitosis to destabilize securin, which will be beneficial for mitotic progression [32]."
Bisphenol A affects USP24
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Bisphenol A increases the amount of USP24.
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Bisphenol A increases the amount of USP24. 6 / 6
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Bisphenol A decreases the amount of USP24.
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Bisphenol A demethylates USP24.
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reach
"Owing to the absence of structural information on the interaction between USP24 and YAP1, we generated a complex structural model of the interaction between USP24 and YAP1 by using the AlphaFold3 server [36], which provided a structural view to understand the interactions between USP24 and YAP1."
sparser
"Owing to the absence of structural information on the interaction between USP24 and YAP1, we generated a complex structural model of the interaction between USP24 and YAP1 by using the AlphaFold3 server [ xref ], which provided a structural view to understand the interactions between USP24 and YAP1."
USP24 affects response to xenobiotic stimulus
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USP24 activates response to xenobiotic stimulus.
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USP24 activates response to xenobiotic stimulus. 7 / 7
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"The detailed cell death signal pathway(s) triggered by targeting USP24 need to be clarified in the future.In addition to the gene expression involved in lung cancer progression, other genes related to other pathways involved in hematopoietic disease, dermatomyositis, leukocyte migration/cell-cell adhesion/chemotaxis and fat cell differentiation might also be related to USP24-mediated drug resistance."
reach
"The data indicated that the tumor area in the gefitinib-induced EGFR *USP24 drug-resistant mice was inhibited compared with that in the gefitinib-induced EGFR *USP24 drug-resistant mice, indicating that USP24 promotes drug resistance acquired during cancer therapy (Fig. 5C, upper panel)."
USP24 inhibits response to xenobiotic stimulus.
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USP24 inhibits response to xenobiotic stimulus. 5 / 5
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reach
"In summary, an increase in the expression of USP24 in cancer cells is beneficial for the induction of drug resistance and targeting USP24 by USP24-i-101 optimized from USP24-i inhibits drug resistance acquired during cancer therapy by increasing PD-L1 protein degradation and genomic stability in an autophagy induction-dependent manner."
reach
"USP24 regulated and stabilized the protein levels of NCOA4 thereby promoting ferritinophagy during HCMV infection, while the binding of USP24 to pUL38 was able to reduce ferritinophagy to promote iron-dependent ER stress-induced cell death (Santana-Codina and Mancias, 2018; Sun et al., 2018)."
USP24 affects apoptotic process
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USP24 activates apoptotic process.
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USP24 inhibits apoptotic process.
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USP24 affects ferroptosis
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reach
"USP24 regulated and stabilized the protein levels of NCOA4 thereby promoting ferritinophagy during HCMV infection, while the binding of USP24 to pUL38 was able to reduce ferritinophagy to promote iron-dependent ER stress-induced cell death (Santana-Codina and Mancias, 2018; Sun et al., 2018)."
reach
"We also found that ubiquitin-specific peptidase 24 (USP24) protected p38-phosphorylated Runx2 (pRunx2) from ubiquitin-dependent proteasomal degradation, thereby enabling pRunx2 to recruit two transcriptional regulators, namely p300 (a histone acetyltransferase) and the nuclear receptor coactivator 3 (NCOA3), to assemble a NCOA3-p300-pRunx2 complex."
USP24 affects EV71
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reach
"In cancer cells, USP24 increased p300 and beta-TrCP, thus increasing the acetylation of histone H3 and the degradation of DNMT1 and IkappaB, resulting in the recruitment of histone H3 acetylation to the promoter region of IL-6, the reduction of DNA methylation, and the promotion of NF-kappaB nuclear translocation, thereby facilitating IL-6 expression."
USP24-i-101 affects USP24
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USP24-i-101 inhibits USP24.
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reach
"In summary, an increase in the expression of USP24 in cancer cells is beneficial for the induction of drug resistance and targeting USP24 by USP24-i-101 optimized from USP24-i inhibits drug resistance acquired during cancer therapy by increasing PD-L1 protein degradation and genomic stability in an autophagy induction-dependent manner."
USP24-i-101 decreases the amount of USP24.
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USP24-i-101 activates USP24.
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USP24 is inactive.
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USP24 is active.
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"Taken together, these data suggest that the ATM kinase mediated phosphorylation of USP24 is involved in USP24 stabilization/up regulation following UV irradiation.|Taken together, these data suggest that the ATM kinase-mediated phosphorylation of USP24 is involved in USP24 stabilization/up-regulation following UV irradiation."
USP24 affects Infections
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USP24 activates Infections.
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USP24 inhibits Infections.
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sparser
"Loss of the interaction motif of USP24 eliminated the ability of USP24 to stabilize BRD-containing proteins and abolished the effect of USP24 on cancer progression, including its inhibition of cancer cell proliferation and promotion of cancer cell migration, suggesting that the interaction between USP24 and the BRD is important for USP24-mediated effects on cancer progression."
sparser
"Owing to the absence of structural information on the interaction between USP24 and the BRD, we generated a structural model of the catalytic domain of human USP24 (USP24-CD) by using the SWISS-MODEL server, and a complex structural model of the interaction between USP24-CD and the second BRD of human BRD2 (BRD2-BD2) was built up by using the ZDOCK server, which provided a structural view to understand the interactions between USP24-CD and BRD2-BD2 (Fig. xref G(a))."
sparser
"Loss of the interaction motif of USP24 eliminated the ability of USP24 to stabilize BRD-containing proteins and abolished the effect of USP24 on cancer progression, including its inhibition of cancer cell proliferation and promotion of cancer cell migration, suggesting that the interaction between USP24 and the BRD is important for USP24-mediated effects on cancer progression."
sparser
"Owing to the absence of structural information on the interaction between USP24 and the BRD, we generated a structural model of the catalytic domain of human USP24 (USP24-CD) by using the SWISS-MODEL server, and a complex structural model of the interaction between USP24-CD and the second BRD of human BRD2 (BRD2-BD2) was built up by using the ZDOCK server, which provided a structural view to understand the interactions between USP24-CD and BRD2-BD2 (Fig. xref G(a))."
USP24 affects Parkinson Disease
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USP24 inhibits Parkinson Disease.
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USP24 ubiquitinates Parkinson Disease.
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USP24 leads to the ubiquitination of Parkinson Disease. 1 / 1
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USP24 binds Parkinson Disease.
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USP24 binds Parkinson Disease. 1 / 1
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reach
"Targeting USP24 by USP24-i-101 induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively, thereby inhibiting the expression of ABCG2 and PD-L1 and maintaining genomic integrity, resulting in the inhibition of drug resistance acquired by gefitinib- or Taxol-treatment of lung cancer (Fig. 8D)."
"Taken together, these data suggest that the ATM kinase mediated phosphorylation of USP24 is involved in USP24 stabilization/up regulation following UV irradiation.|Taken together, these data suggest that the ATM kinase-mediated phosphorylation of USP24 is involved in USP24 stabilization/up-regulation following UV irradiation."
"Taken together, these data suggest that the ATM kinase mediated phosphorylation of USP24 is involved in USP24 stabilization/up regulation following UV irradiation.|Taken together, these data suggest that the ATM kinase-mediated phosphorylation of USP24 is involved in USP24 stabilization/up-regulation following UV irradiation."
USP24 affects cell death
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USP24 activates cell death.
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USP24 inhibits cell death.
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USP24 inhibits cell death. 1 / 1
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EOAI3402143 affects USP24
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USP24 affects glycolytic process
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USP24 affects WP1130
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reach
"In this study, we discovered the underlying mechanisms by which USP24 not only promotes IkappaB degradation by stabilizing beta-transduction repeat containing E3 ubiquitin protein ligase (beta-TrCP) in lung cancer cells but also induces the upregulation of NF-kappaB in M2 macrophages, resulting in an increase in IL-6 expression."
reach
"In this study, we discovered the underlying mechanisms by which USP24 not only promotes IkappaB degradation by stabilizing beta-transduction repeat containing E3 ubiquitin protein ligase (beta-TrCP) in lung cancer cells but also induces the upregulation of NF-kappaB in M2 macrophages, resulting in an increase in IL-6 expression."
USP24 affects Histone_H3
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USP24 acetylates Histone_H3.
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USP24 leads to the acetylation of Histone_H3. 3 / 3
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reach
"As an example, USP24, a deubiquitinating enzyme upregulated in M2 macrophages of lung cancer cells, could stabilize HAT p300 thus increase H3 acetylation and NF-κB while decrease DNMT1, subsequently elevating TNF-α and IL-6 transcription, ultimately resulting in cancer malignancy [175]."
USP24 increases the amount of Histone_H3.
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USP24 increases the amount of Histone_H3. 1 / 1
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USP24 affects Carcinogenesis
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Infections affects USP24
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Infections increases the amount of USP24.
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Infections increases the amount of USP24. 2 / 2
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Infections activates USP24.
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Infections activates USP24. 2 / 2
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EV71 affects USP24
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Sodium arsenite affects USP24
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Sodium arsenite decreases the amount of USP24.
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Sodium arsenite increases the amount of USP24.
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Orf10 affects USP24
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MiR-139-5p affects USP24
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USP24 affects orf10
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USP24 affects miR-21-5p inhibitor
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USP24 increases the amount of USP24.
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reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR Our recent study showed that USP24 variants from SNPs and RNA editing products increased the levels of USP24 and MDM2, which regulates Suv39h1 in lung cancer cells, subsequently resulting in an increase in metastatic activities during lung cancer progression."
USP24 inhibits USP24.
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USP24 affects Stomach Neoplasms
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USP24 affects Neoplasm Metastasis
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USP24 affects Interferon
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USP24 affects IFN-I
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USP24 affects Genomic Instability
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USP24 activates Genomic Instability.
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USP24 activates Genomic Instability. 2 / 2
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reach
"Increased levels of USP24 lead to p53 stabilization and upregulation and subsequent activation of p53 downstream targets.can be reversed by the action of DUBs.Thus, targeting DUBs may have promising potential in cancer therapy.9 USP24offers novel exciting perspectives in basicand translational research, and anapoptosis and genome stability."
reach
"LC3-II was significantly increased in mitotic A549 cells but not in A549-T24 cells (Fig. 3E(a), Fig. 3E(b) and Fig. 3E(d)), implying that the downregulation of USP24 may induce autophagy to maintain genomic stability in drug-sensitive lung cancer cells but not in drug-resistant lung cancer cells (Fig. 3E)."
USP24 inhibits Genomic Instability.
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USP24 inhibits Genomic Instability. 1 / 1
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reach
"Increased levels of USP24 lead to p53 stabilization and upregulation and subsequent activation of p53 downstream targets.can be reversed by the action of DUBs.Thus, targeting DUBs may have promising potential in cancer therapy.9 USP24offers novel exciting perspectives in basicand translational research, and anapoptosis and genome stability."
sparser
"Collectively, these findings implied that the L1-FGGY reduces the expression of FGGY, thereby, facilitating the binding of more USP24 to GPR31 that increases GPR31 de-ubiquitination and activation of metabolic pathway for AA/12-LOX/12S-HETE and the subsequent signaling through the Wnt pathway in tumor cells for enhanced cell proliferation and invasion (Figure S xref )."
sparser
"Then we detected binding of USP24 with FGGY or GPR31 (Fig. xref J), illustrating the physical interaction of USP24 with either FGGY or GPR31, whereby, the ubiquitination of GPR31 was increased by USP24 knockdown (Fig. xref K) to indicate that USP24 acts as a deubiquitination enzyme of GPR31."
ORF10 activates USP24.
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sparser
"Collectively, these findings implied that the L1-FGGY reduces the expression of FGGY, thereby, facilitating the binding of more USP24 to GPR31 that increases GPR31 de-ubiquitination and activation of metabolic pathway for AA/12-LOX/12S-HETE and the subsequent signaling through the Wnt pathway in tumor cells for enhanced cell proliferation and invasion (Figure S xref )."
sparser
"Then we detected binding of USP24 with FGGY or GPR31 (Fig. xref J), illustrating the physical interaction of USP24 with either FGGY or GPR31, whereby, the ubiquitination of GPR31 was increased by USP24 knockdown (Fig. xref K) to indicate that USP24 acts as a deubiquitination enzyme of GPR31."
Zoledronic acid affects USP24
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Valproic acid affects USP24
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Paracetamol affects USP24
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Manganese atom affects USP24
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Manganese atom increases the amount of USP24.
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Manganese atom decreases the amount of USP24.
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Benzo[a]pyrene diol epoxide I affects USP24
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Arsenic atom affects USP24
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Arsenic atom increases the amount of USP24.
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Arsenic atom decreases the amount of USP24.
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USP24 affects immune response
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USP24 inhibits immune response.
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USP24 inhibits immune response. 1 / 1
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USP24 activates immune response.
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USP24 activates immune response. 1 / 1
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USP24 affects cell cycle
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USP24 activates cell cycle. 2 / 2
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"Overexpression of E2F4 in USP24 silenced cells rescued only the E2F1 mRNA level and partially abolished the effect of the USP24 knockdown on the G1-S transition and colony formation (XREF_FIG; XREF_SUPPLEMENTARY), implying that E2F4 might be involved in USP24 mediated cell cycle progression."
USP24 affects activation IFNbeta
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eidos
"USP2-4 also inhibited the activation of the IFNbeta promoter by modulating retinoic acid-inducible gene-I ( RIG-I ) , melanoma differentiation-associated gene 5 ( MDA5 ) , mitochondrial antiviral signaling protein ( MAVS ) , TANK binding kinase 1 ( TBK1 ) , and possibly activating interferon regulatory factor 3 ( IRF3 ) [ 155 ] ."
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USP24 affects Proteasome
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USP24 deubiquitinates Proteasome.
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USP24 leads to the deubiquitination of Proteasome. 1 / 1
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USP24 binds Proteasome.
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USP24 binds Proteasome. 1 / 1
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USP24 affects PUL38
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USP24 affects Neuroblastoma
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reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR Our recent study showed that USP24 variants from SNPs and RNA editing products increased the levels of USP24 and MDM2, which regulates Suv39h1 in lung cancer cells, subsequently resulting in an increase in metastatic activities during lung cancer progression."
USP24 affects GSDMB protein bladder cancer
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USP24 affects Carcinoma, Hepatocellular
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USP24 activates Carcinoma, Hepatocellular. 2 / 2
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USP24 affects Aneuploidy
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reach
"Targeting USP24 by USP24-i-101 induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively, thereby inhibiting the expression of ABCG2 and PD-L1 and maintaining genomic integrity, resulting in the inhibition of drug resistance acquired by gefitinib- or Taxol-treatment of lung cancer (Fig. 8D)."
Particulate Matter affects USP24
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Parkinson Disease affects USP24
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Parkinson Disease increases the amount of USP24.
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Parkinson Disease increases the amount of USP24. 1 / 1
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Parkinson Disease binds USP24.
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USP24 binds Parkinson Disease. 1 / 1
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PUL38 affects USP24
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1,2-dimethylhydrazine affects USP24
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4,4'-sulfonyldiphenol affects USP24
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4,4'-sulfonyldiphenol increases the amount of USP24.
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4,4'-sulfonyldiphenol decreases the amount of USP24.
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ΜM. affects USP24
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Α-IL-6 affects USP24
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Troglitazone affects USP24
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Triptonide affects USP24
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Trichostatin A affects USP24
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Sodium fluoride affects USP24
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Protein pUL38 affects USP24
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Potassium chromate affects USP24
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Perfluorooctane-1-sulfonic acid affects USP24
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Patients tumors affects USP24
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PUL38 protein affects USP24
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Oxaliplatin affects USP24
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Nickel atom affects USP24
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Mono(2-ethylhexyl) phthalate affects USP24
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MiR-363 affects USP24
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reach
"It is noteworthy that miR-25 targeting BMPR2 and IRS1, miR-363 targeting USP24, miR-28 targeting HECW2 and miR-210 targeting ATP5I, ME3, MTCH1 and CPT2 were highly associated with slow-twitch oxidative fibers, fast-twitch oxidative fibers, ADP and ATP concentration suggesting an essential role of the miRNA mRNA regulatory networking in modulating the mitochondrial energy expenditure in the porcine muscle."
MiR-21-5p affects USP24
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Methylmercury chloride affects USP24
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Methidathion affects USP24
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Methapyrilene affects USP24
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Manganese(II) chloride affects USP24
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Ivermectin affects USP24
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Irinotecan affects USP24
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Indometacin affects USP24
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Hsa-miR-1226-3p affects USP24
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Ginger extract affects USP24
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Ferrostatin-1 affects USP24
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Ferrostatin-1 inhibits USP24. 1 / 1
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Factor 2 affects USP24
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Doxycycline affects USP24
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Doxycycline activates USP24. 1 / 1
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Dexamethasone affects USP24
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Deoxynivalenol affects USP24
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Deltamethrin affects USP24
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Decabromodiphenyl ether affects USP24
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Cyclosporin A affects USP24
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Certain affects USP24
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Cefaloridine affects USP24
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Cadmium dichloride affects USP24
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Bisphenol F affects USP24
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Benzo[a]pyrene affects USP24
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Auramine O affects USP24
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Aristolochic acid A affects USP24
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USP24 affects γ-H2AX
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USP24 affects wound healing
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USP24 inhibits wound healing. 1 / 1
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USP24 affects whole-chromosome aneuploidy
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USP24 affects ubiquitination RUNX2
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USP24 affects surface Cav1.2
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USP24 affects sodium distribution body
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USP24 affects proteolytic cleavage extracellular loop alphaENaC
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USP24 affects protein pUL38
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USP24 affects protein beta-TrCP p300
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USP24 affects process
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USP24 affects pathway
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sparser
"Ubiquitin‐specific peptidase 24 (USP24) is a member of the DUB family and contains a ubiquitin related domain (UBA) and a ubiquitin C‐terminal hydrolase (UCH) domain, which is the catalytic domain. xref USP24 is rarely reported, but it plays an important regulatory role in tumors. xref , xref It has been reported that USP24 increases interleukin‐6 transcription in M2 macrophages and lung cancer cells in lung cancer. xref USP24 increases the level and stability of most BRD‐containing proteins by removing ubiquitin from BRD Lys391/Lys400. xref In bladder cancer, USP24 activates the STAT3 pathway by stabilizing GSDMB and promotes the growth and invasion ability of bladder cancer cells. xref However, the mechanism of USP24 in gastric cancer remains unclear."
USP24 affects pUL38 protein
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USP24 affects mouse model
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USP24 affects miR-21-5p
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USP24 affects metastasis breast cancer
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USP24 affects lysosomal
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USP24 affects localization
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USP24 activates localization. 1 / 1
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USP24 affects interphase
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USP24 activates interphase. 1 / 1
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USP24 affects glutathione
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USP24 inhibits glutathione. 1 / 1
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USP24 affects formation
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USP24 affects factor 2
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USP24 affects evasion of host immune response
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USP24 activates evasion of host immune response. 1 / 1
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USP24 affects deubiquitination GSDMB
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USP24 affects cytokine production
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USP24 inhibits cytokine production. 1 / 1
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USP24 affects cyclin B1
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USP24 affects circadian rhythm calcium permeability
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USP24 affects chromosome separation
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USP24 activates chromosome separation. 1 / 1
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USP24 affects cancer malignancy
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USP24 affects autophagy of mitochondrion
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USP24 inhibits autophagy of mitochondrion. 1 / 1
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1
USP24 affects USP24-i-101
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USP24 affects USP24-7656C
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USP24 affects ULK1 ubiquitination
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USP24 affects TME.USP24 mRNA
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USP24 affects SeV-elicited TBK1
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1
USP24 affects PtdIns3P
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USP24 affects MDM2 well-known E3 ligase P53 lung cancer
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USP24 affects LC3-II
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USP24 affects ISGs
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USP24 affects ISG [ 61 ]
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USP24 affects GSDMB protein
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eidos
"USP24 stabilizes GSDMB to promote STAT3 phosphorylation in bladder cancer cells Given that USP24 promoted the expression of the GSDMB protein levels rather than that of the mRNA levels in bladder cancer cells , we hypothesized that USP24 may regulate the stability of GSDMB through the ubiquitinated proteasome pathway ."
reach
"Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness, but also increased the levels of the ATP binding cassette (ABC) transporters P-gp, ABCG2, and ezrin to enhance the pumping out of Taxol from cancer cells, thus resulted in drug resistance during cancer therapy."
reach
"Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness, but also increased the levels of the ATP binding cassette (ABC) transporters P-gp, ABCG2, and ezrin to enhance the pumping out of Taxol from cancer cells, thus resulted in drug resistance during cancer therapy."
USP24 affects Cell Survival
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USP24 activates Cell Survival. 1 / 1
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USP24 affects CRISPR-associated protein
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USP24 inhibits CRISPR-associated protein. 1 / 1
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USP24 be compensated affects USP24
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USP inhibitor affects USP24
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Proteasome affects USP24
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USP24 binds Proteasome. 1 / 1
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1
Other factor(s) affects USP24
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1
NF-kappa B. J Neurochem 2014 affects USP24
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1
LC3-II affects USP24
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1
FTI-276 affects USP24
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1
reach
"Overexpression of E2F4 in USP24 silenced cells rescued only the E2F1 mRNA level and partially abolished the effect of the USP24 knockdown on the G1-S transition and colony formation (XREF_FIG; XREF_SUPPLEMENTARY), implying that E2F4 might be involved in USP24 mediated cell cycle progression."
Air Pollutants affects USP24
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2,4,6-tribromophenol affects USP24
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1-phenylpropan-2-amine affects USP24
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