IndraLab

Statements

USP24 activates BTRC. 3 / 3
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"This study shows that USP24 mediates p300, NF-kappaB, DNMT1, and beta-TrCP to regulate IL-6 expression, thus affecting cancer metastasis."
30266897
reach
"To further clarify whether USP24 directly targets beta-TrCP for deubiquitination, an in vitro deubiquitination assay was performed, and purified human USP24 significantly decreased the beta-TrCP ubiquitination signal."
30266897
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"In cancer cells, USP24 increased p300 and beta-TrCP, thus increasing the acetylation of histone H3 and the degradation of DNMT1 and IkappaB, resulting in the recruitment of histone H3 acetylation to the promoter region of IL-6, the reduction of DNA methylation, and the promotion of NF-kappaB nuclear translocation, thereby facilitating IL-6 expression."
30266897