IndraLab

Statements

USP24 activates EP300. 5 / 5
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"This study shows that USP24 mediates p300, NF-kappaB, DNMT1, and beta-TrCP to regulate IL-6 expression, thus affecting cancer metastasis."
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"Thus, GFP-USP24 increased p300 protein stability, whereas knockdown USP24 decreased its stability (XREF_FIG; XREF_SUPPLEMENTARY) and USP24 interacted with p300 (XREF_FIG)."
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"USP24 induces apoptosis by stabilizing p300 and Bax."
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"In cancer cells, USP24 increased p300 and beta-TrCP, thus increasing the acetylation of histone H3 and the degradation of DNMT1 and IkappaB, resulting in the recruitment of histone H3 acetylation to the promoter region of IL-6, the reduction of DNA methylation, and the promotion of NF-kappaB nuclear translocation, thereby facilitating IL-6 expression."
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"Because our previous study confirmed that p300 is a USP24 substrate in lung cancer cells 31, we wanted to confirm whether p300 is also directly regulated by USP24 in M2 macrophages."
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