IndraLab

Statements

WP1130 inhibits USP24. 7 / 7
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"The reason we were unable to detect other DUBs that WP1130 is known to target might be due to the use of USP18 overexpressing lysates (as we observed WP1130 competitively blocks the labeling of USP9X and USP24 in HEK293T cell lysates, data not shown) and the reversible nature of modification by WP1130."
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"Collectively, these results demonstrate that WP1130 could inhibit T-ALL cell growth and USP24 activity in vivo."
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"Consistently, the inhibition of USP24 by WP1130 apparently blocked the ability of USP24 to remove ubiquitin chains from YAP1 (Fig. 3B)."
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"The aim of this study was to explore whether WP1130 could suppress T-ALL and the role of USP24 in T-ALL."
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"It should be also noted, however, that G9, as well as WP1130, was recently reported to inhibit USP24 as well as USP5 in addition to USP9X [37]."
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"WP1130 could inhibit the DUB activity of USP9X, USP5, USP14, USP37 and USP24 [ 84 ]."
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"However, we found that several reported DUB inhibitors, including WP1130 (a known inhibitor of USP5, USP9X, USP14, USP24, and UCH37, Figure 4B), inhibit USP18 protease activity in an ISG15-Rho assay (Figure S8)."
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