IndraLab

Statements

USP24 inhibits response to xenobiotic stimulus. 5 / 5
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"USP24, another ubiquitinating enzyme, induces autophagy in vivo and in vitro and inhibits drug resistance in cancers acquired by taxol or gefitinib treatment [14]."
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"In addition, rapamycin-induced autophagy was also essential for the effect of USP24 in inhibiting the drug resistance to Taxol and gefitinib (Supplementary Fig. 3C, D)."
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"USP24 functional knockout inhibits drug resistance in drug resistant mice with gefitinib-induced EGFR L858R lung cancer."
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"In summary, an increase in the expression of USP24 in cancer cells is beneficial for the induction of drug resistance and targeting USP24 by USP24-i-101 optimized from USP24-i inhibits drug resistance acquired during cancer therapy by increasing PD-L1 protein degradation and genomic stability in an autophagy induction-dependent manner."
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"Targeting USP24 by USP24-i-101 inhibits drug resistance in vivo."
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