IndraLab

Statements

USP24 activates PDCD1. 9 / 9
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"Together, our findings suggested that USP24 enhances PD-1 stability and therefore leads to T cell immunosuppression."
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"IL-6 increases USP24 expression to enhance PD-1 stability."
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"Deubiquitinase USP24 activated by IL-6/STAT3 enhances PD-1 protein stability and suppresses T cell antitumor response."
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"Our study demonstrated that USP24 promotes PD-1 protein stability in both CD4 and CD8 T cells and also increases levels on TAMs, suggesting USP24 as a universal regulator in PD-1 expression."
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"Here, we show that ubiquitin-specific peptidase 24 (USP24) promotes PD-1 protein stability by removing K48-linked polyubiquitin."
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"The potential of α-IL-6 for enhancing T cell function warrants further investigation.In conclusion, we reveal that IL-6/STAT3/NF-κB transcriptionally activates USP24 to drive USP24-mediated deubiquitinating machinery to stabilize PD-1 and suppress T cell activity."
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"USP24 promotes PD-1 protein stability, leading to T cell inactivation."
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"Moreover, ectopically expressing GFP-USP24 increased PD-1 membrane presentation, whereas knockdown of USP24 reduced the PD-1 level on the cell surface (Fig. 2C)."
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"These results prompted us to examine whether USP24 inhibition blocks PD-1/PD-L1–mediated T cell inhibition."
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