IndraLab

Statements


USP24 increases the amount of EP300. 5 / 5
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"In M2 macrophages, USP24 increased p300 levels, subsequently enhancing the levels of NF-kappaB and IL-6."

"In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its substrates in samples from clinical lung cancer patients. |Knockdown of USP24 decreases Bax and p300 levels"

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"Similarly, USP24 knockdown decreases p300 levels by decreasing p300 protein stability."

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"Similarly, knockdown of USP24 decreased the p300 level but did not affect its mRNA level (XREF_FIG)."

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"Up-regulated USP24 increased the protein level of β-TrCP and p300 to promote lung cancer malignancy 31."