IndraLab

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USP24 decreases the amount of IL6. 2 / 2
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"Furthermore, USP24 stabilizes p300 and reduces the levels of DNMT1, thereby increasing IL-6 transcription in M2 macrophages and lung cancer cells (107)."
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"After analyzing the five CpG sites upstream of the transcription start site, we found that the methylation status of a CpG site located at -123 was increased in A549 cells but not in M2 macrophages after USP24 knockdown, indicating that a decrease in IL-6 methylation induced by USP24 in A549 cells, but not in M2 macrophages, increases IL-6 mRNA levels."
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