IndraLab

Statements


USP24 leads to the deubiquitination of ULK1. 3 / 3
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"We detected increased levels of ULK1 ubiquitination following USP24 knockdown as compared to nt controls)."

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"Our data indicate that USP24 knockdown leads to increase in ULK1 ubiquitination, increased ULK1 protein stability and kinase activity."

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"These data suggest that USP24 normally negatively regulates ubiquitination and stability of ULK1, therefore interrupting the positive feed-back amplifying induction of autophagy."