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GPR31 binds USP24. 3 / 3
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"The interaction of GPR31 with USP24 was increased in H520OV− L1−FGGY cells (Fig.  xref L) by using an immunoprecipitation assay, whereas, the total USP24 protein level in cell lysates did not change."
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"Collectively, these findings implied that the L1-FGGY reduces the expression of FGGY, thereby, facilitating the binding of more USP24 to GPR31 that increases GPR31 de-ubiquitination and activation of metabolic pathway for AA/12-LOX/12S-HETE and the subsequent signaling through the Wnt pathway in tumor cells for enhanced cell proliferation and invasion (Figure S xref )."
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"Then we detected binding of USP24 with FGGY or GPR31 (Fig.  xref J), illustrating the physical interaction of USP24 with either FGGY or GPR31, whereby, the ubiquitination of GPR31 was increased by USP24 knockdown (Fig.  xref K) to indicate that USP24 acts as a deubiquitination enzyme of GPR31."
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