IndraLab

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USP24 inhibits ULK1. 3 / 3
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"USP24 has been reported to inhibit autophagy in neurons by increasing the degradation of ULK1 to repress the human induced-pluripotent stem cell (iPSC) differentiation into dopaminergic neurons, which is involved in Parkinson’s disease (PD) [35]."
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"USP24 knockdown decreased degradation of the ULK1 protein in the presence of protein synthesis inhibitor, cycloheximide)."
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"While the deubiquitinating enzyme USP20 and STAMBP/AMSH promote autophagy initiation by stabilizing ULK1 [21, 46], USP24 was found to negatively regulate autophagy and the stability of ULK1 [47]."
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