IndraLab

Statements

EOAI3402143 inhibits USP24. 4 / 4
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"Furthermore, we improved the drug like properties of WP1130 and demonstrated that the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice."
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"The novel inhibitor EOAI3402143 proved to inhibit both Usp9x and Usp24 activity and suppresses tumor growth in vivo [XREF_BIBR]."
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"Another novel small molecule , EOAI3402143 ( with properties similar to WP1130 ) , selectively inhibits USP9X and USP24 , induces apoptosis in malignant B-cell lines , and also blocks or regresses myeloma tumors in mice [ 127 ] ."
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"A more novel inhibitor EOAI3402143 inhibited Usp9x and Usp24 activity in a dose dependent manner and resulted in the induction of apoptosis."
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