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USP24 activates GSDMB. 3 / 3
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"These data suggest that USP24 promoted the stability of the GSDMB protein in bladder cancer by deubiquitinating GSDMB.Moreover, after USP24 was inhibited or overexpressed, the expression level of p-STAT3 Y705 also decreased or increased, respectively (Fig. 6I-K)."
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"This process is further enhanced by USP24, which prevents the degradation of GSDMB [166]."
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"USP24 can also prevent the degradation of GSDMB in bladder cancer cells to stabilize GSDMB to activate STAT3 phosphorylation; Enhance the growth and invasion of bladder cancer cells [ 49 ]."
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