IndraLab

"Ubiquitin‐specific peptidase 24 (USP24) is a member of the DUB family and contains a ubiquitin related domain (UBA) and a ubiquitin C‐terminal hydrolase (UCH) domain, which is the catalytic domain. xref USP24 is rarely reported, but it plays an important regulatory role in tumors. xref , xref It has been reported that USP24 increases interleukin‐6 transcription in M2 macrophages and lung cancer cells in lung cancer. xref USP24 increases the level and stability of most BRD‐containing proteins by removing ubiquitin from BRD Lys391/Lys400. xref In bladder cancer, USP24 activates the STAT3 pathway by stabilizing GSDMB and promotes the growth and invasion ability of bladder cancer cells. xref However, the mechanism of USP24 in gastric cancer remains unclear."