IndraLab

Statements

USP24 activates HYCC1. 11 / 11
| 11
reach
"Taken together, USP24 can be employed as a promising target to restrain tumor growth and increase the efficacy of HCC immunotherapy."
39127151
reach
"The results indicated that USP24 overexpression decreased wound-healing ability (Fig. 5F and Supplementary Fig. 3A, B) and inhibited the migration of HCC cells (Fig. 5G, H)."
39379617
reach
"Depletion of USP24 significantly suppressed the proliferation of HCC cells in vitro, which could be rescued by restoration of YAP1."
40287768
reach
"Knocking down USP24 promotes HCC proliferation and migration, whereas USP24 overexpression inhibits HCC in vitro and in vivo."
39379617
reach
"We find that increased autophagy is accompanied by ferroptosis in USP24 overexpressed HCC cells and USP24 increases the susceptibility of HCC to sorafenib."
39379617
reach
"These results suggested that USP24 promotes ferroptosis of HCC cells.Taking into account that ferroptosis is a type of autophagic cell death, which we called ferritinophagy , the Fe level was measured using a colorimetric assay and a fluorescence probe."
39379617
reach
"Altogether, these results demonstrate that USP24 levels are significantly elevated in HCC and that its expression also plays an important role in predicting the clinical outcomes of patients with HCC."
40287768
reach
"The results indicated that overexpression of USP24 decreased GSH while increased the level of MDA in HCC cells (Fig. 7H, I and Supplementary Fig. 4G, H), further confirming that USP24 promotes ferroptosis in HCC cells."
39379617
reach
"To investigate whether USP24 knockdown suppressed the tumorigenesis of HCC cells in vivo, we injected Bel-7402 cells which were stably knockdown USP24 (shUSP24-2) or the negative control (shNC) into the subcutaneous of the nude mice."
40287768
reach
"USP24 markedly promoted HCC proliferation and progression in vitro and in vivo."
39127151
reach
"In addition, we also found that USP24 promoted cell proliferation and tumor growth of HCC in vitro and in vivo."
40287768