IndraLab

Statements

USP24-i-101 inhibits USP24. 5 / 5
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"One possibility is that USP24-i-101 treatment can rapidly inhibit all USP24 activity, but this activity is only partially silenced by shRNA, and this process requires 2-3 days."
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"USP24-i-101 blocks USP24 enzyme activity to decrease PD-1 protein stability."
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"In summary, an increase in the expression of USP24 in cancer cells is beneficial for the induction of drug resistance and targeting USP24 by USP24-i-101 optimized from USP24-i inhibits drug resistance acquired during cancer therapy by increasing PD-L1 protein degradation and genomic stability in an autophagy induction-dependent manner."
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"These findings suggest that USP24-i-101 may impair USP24 protein stability, implying that USP24 could control its own protein stability."
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"These data indicated that USP24-i-101 specifically blocks USP24 activity to decrease PD-1 stability.We then investigated whether USP24-i-101 increased T cell anticancer activity (fig."
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