IndraLab

"There areseveral possible reasons for this : first, different DUBs might regulate the p53pathway in response to different cellu-lar stresses; second, different DUBsmight work in different cellular com-partments; and third, since p53 is suchan important protein that is ubiquiti nated by many different E3 ligases, dif-ferent DUBs may be required tocounteract p53 ubiquitination of dif-ferent ubiquitin linkage topologies.Indeed, it is known that DUBs havedifferent types of substrate cleavageactivities -- some generate free ubiqui-tin from linear substrate, some removeubiquitin from post-translationallymodified protein, and others edit polyubiquitin chains.10 A survey of the Catalog Of SomaticMutations In Cancer (COSMIC) data-base shows that USP24 is frequently mutated in various human cancers.6 Since p53 is a well-known tumor sup-pressor that regulates cell proliferationand USP24 potentiates p53 function byFigure 1."

"Moreover, we showed that the regulation of p53 activation by USP24 is not mediated by mouse double minute 2 homolog (Mdm2), its major E3 ligase."

"Evidence that USP24 targets p53 to protect genome stability."

"USP24 can directly regulate the activation of p53 (TP53) to facilitate DNA repair."

"USP24 targeting DDB2 and p53."

"It has been shown that USP24 targets p53 to regulate UV induced apoptosis."