The INDRA Database

sparser

"USP24 interacts with Beclin1."

39379617

sparser

"The interaction between USP24 and Beclin1 represents a key molecular mechanism that promotes autophagy related ferroptosis in HCC."

39379617

➶

sparser

"It was found that Beclin1 could be co-immunoprecipitated by USP24 (Fig. xref ), but no other autophagy proteins, such as ULK1 and Atg5 (Supplementary Fig. xref ), indicating that USP24 could interact with Beclin1."

39379617

➶

sparser

"Next, a reciprocal Co-IP assay was conducted to further confirm the interaction between USP24 and Beclin1 (Fig. xref )."

39379617

➶

sparser

"Additionally, cellular double immunofluorescence assay provided morphological evidence of the interaction between USP24 and Beclin1 protein (Fig. xref and Supplementary Fig. xref ) and the colocalization coefficients increased after USP24 overexpression (Fig. xref and Supplementary Fig. xref )."

39379617

➶

sparser

"USP24 interacts endogenously with Beclin 1 and delays its degradation by reducing K48-linked ubiquitination."

40687997

➶

sparser

"These results collectively confirmed the interaction between USP24 and Beclin1."

39379617

➶

reach

"The endogenous interaction between USP24 and Beclin1 is confirmed."

39379617

➶

reach

"Next, a reciprocal Co-IP assay was conducted to further confirm the interaction between USP24 and Beclin1 (Fig. 4B)."

39379617

➶

sparser

"To the best of our knowledge, this is the first evidence demonstrating that USP24 interacts with Beclin1, primarily by inhibiting its K48-linked ubiquitination."

39379617

➶

reach

"These results collectively confirmed the interaction between USP24 and Beclin1."

39379617

➶

reach

"The interaction between USP24 and Beclin1 represents a key molecular mechanism that promotes autophagy-dependent ferroptosis."

39379617

➶

sparser

"The interaction between USP24 and Beclin1 represents a key molecular mechanism that promotes autophagy-dependent ferroptosis."