IndraLab

Statements

KRAS-G12D decreases the amount of USP24. 3 / 3
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"Taken together, these data revealed that Kras G12D - or EGFR L858R -mediated pathways negatively regulated USP24 expression, which might trigger lung cancer formation."
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"XREF_BIBR, XREF_BIBR Although their levels were increased in some specimens from late-stage lung cancer patients, inhibition of Kras G12D - or EGFR L858R -mediated activities in all cell lines at different stages increased the USP24 level."
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"Based on the data in this study and our previous study, we propose that EGFR L858R - and Kras G12D -mediated signaling pathways inhibit USP24 expression, which is beneficial for cancer formation during the early stage."
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