IndraLab

Statements

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"For example, USP24 positively regulates drug resistance partially by stabilizing ABC transporters, including ABCB1, ABCG1, and ABCC1, to pump out drugs from cancer cells [61]."
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"One study indicated that USP24 stabilized permeability glycoprotein (P-gp) and ATP binding cassette subfamily G member 2 (ABCG2) in a proteosome- and lysosome-dependent manner, respectively [3], implying that lysosomal function may be involved in USP24-mediated drug resistance."
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"All the data indicated that USP24 may positively regulated drug resistance acquired by gefitinib treatment."
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"The detailed cell death signal pathway(s) triggered by targeting USP24 need to be clarified in the future.In addition to the gene expression involved in lung cancer progression, other genes related to other pathways involved in hematopoietic disease, dermatomyositis, leukocyte migration/cell-cell adhesion/chemotaxis and fat cell differentiation might also be related to USP24-mediated drug resistance."
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"Studies have found that USP24 is linked to the progression of lung cancer and can accelerate the occurrence of drug resistance ."
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"The data indicated that the tumor area in the gefitinib-induced EGFR *USP24 drug-resistant mice was inhibited compared with that in the gefitinib-induced EGFR *USP24 drug-resistant mice, indicating that USP24 promotes drug resistance acquired during cancer therapy (Fig. 5C, upper panel)."
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"Our previous studies indicate that USP24 promotes drug resistance acquired through cancer therapy by stabilizing ABC transporters and inducing the genomic instability [3]."
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