IndraLab

Statements

USP24 inhibits HYCC1. 11 / 11
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"Contrary to previous findings , our results indicated that the knockdown of USP24 increased HCC proliferation in vitro, while USP24 overexpression inhibited these processes in vitro and in vivo."
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"It was found that overexpression of USP24 inhibited the proliferation of HCC cells, as indicated by the decrease in both cell viability (Fig. 5C) and colony formation (Fig. 5D, E)."
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"Previous studies have demonstrated that USP24 inhibited proliferation and migration of HCC, and our findings also indicated that USP24 increased cell death in HCC cells (Supplementary Fig. 4A)."
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"In a study by Cao et al., the role of USP24 in inhibiting HCC was investigated."
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"Knocking down USP24 promotes HCC proliferation and migration, whereas USP24 overexpression inhibits HCC in vitro and in vivo."
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"Therefore, overexpression of USP24 induces autophagy along with ferroptosis and reduces sorafenib resistance in HCC [34]."
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"This result suggested that USP24 overexpression combined with sorafenib may synergistically inhibit HCC progression."
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"USP24 silencing promotes HCC cell proliferation and migration in vitro."
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"USP24 inhibits HCC growth in mice xenograft model."
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"Collectively, these results suggested that the knockdown of USP24 promotes the proliferation and migration of HCC cells in vitro."
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"Deletion of USP24 combined with anti-PD-1 antibody significantly enhanced the efficacy of HCC immunotherapy."
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