IndraLab

Statements

GSDMB binds USP24. 14 / 14
2 | 7 5
reach
"Here, our results indicated that USP24 bound to GSDMB to stabilize GSDMB, and subsequently activated the STAT3 pathway in bladder cancer cells."
34326684
sparser
"For example, BUB1 kinase drives bladder cancer progression and proliferation by regulating STAT3 transcription (Jiang et al. xref ); in bladder cancer, USP24-GSDMB complex formation stimulates cell proliferation via STAT3-dependent mechanisms (He et al. xref ); ROC1 gives rise to bladder cancer malignancy via orchestrating NF-κB signaling activation (Wu et al. xref ); Mechanistic studies reveal that secretory granule protein II facilitates bladder cancer advancement by concurrently activating both MAPK and NF-κB pathways (Zhou et al. xref )."
40437145
reach
"Contrary, the interaction between ubiquitin-specific peptidase 24 (USP24) and GSDMB prevents the degradation of gasdermin B in bladder cancer, and this may be a potential therapeutic target in the future [34]."
39766111
biogrid
No evidence text available
34326684
reach
"In bladder cancer, the USP24/GSDMB/STAT3 axis is reported to promote tumor proliferation and growth, where USP24 interacts and stabilizes GSDMB, which in turn binds to STAT3, increases its phosphorylation and activates STAT3 signaling (30)."
35479097
biogrid
No evidence text available
34326684
reach
"It has been reported that USP24 binds to GSDMB to deubiquitinate and stabilize GSDMB."
37497216
sparser
"It has been reported that USP24 bound to Gasdermin B (GSDMB) via the activation of the STAT3 pathway promotes bladder cancer cell proliferation [ xref ]."
38140768
sparser
"Mechanistically, GSDMB forms a complex with USP24, which activates the STAT signaling pathway and, in turn, prevents the degradation of GSDMB, thereby sustaining its oncogenic functions in BLCA [ xref ]."
41003846
reach
"In addition, they confirmed that the interaction between USP24 and GSDMB can prevent degradation of GSDMB in bladder cancer cells [51]."
36702978
sparser
"USP24 interacts with GSDMB to up-regulate the GSDMB protein level."
38395384
sparser
"It has been reported that USP24 binds to GSDMB to deubiquitinate and stabilize GSDMB."
37497216
reach
"USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway."
34326684
reach
"Furthermore, we also demonstrated that USP24 interacted with GSDMB and prevented GSDMB from degradation in bladder cancer cells."
34326684