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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP24 inhibits activation IFNbeta. 2 / 2

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"Moreover , USP2-4 , but not USP2-1 , attenuated the activation of IFNbeta promoter after SeV infection , indicating a role for USP2 in suppressing viral immunity [ 155 ] ."

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"USP2-4 also inhibited the activation of the IFNbeta promoter by modulating retinoic acid-inducible gene-I ( RIG-I ) , melanoma differentiation-associated gene 5 ( MDA5 ) , mitochondrial antiviral signaling protein ( MAVS ) , TANK binding kinase 1 ( TBK1 ) , and possibly activating interferon regulatory factor 3 ( IRF3 ) [ 155 ] ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...