IndraLab

Statements


USP24 increases the amount of MCL1. 3 / 3
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"Thus, EOAI3402143, an inhibitor of the deubiquitinases Usp9x and Usp24, reduced Mcl-1 protein levels in MM cells and lowered disease burden in an animal model of MM [98]."

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"However, WP1130 did not decrease the mRNA level of USP24, but directly inhibited USP24, resulting in a decrease in the level of USP24, which led to a simultaneous decrease in the level of MCL-1."

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"Inhibition of USP9X and USP24 increases the ubiquitination of MCL-1 and decreases the level of MCL-1."