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USP24 increases the amount of IL6. 16 / 16
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"In M2 macrophages, USP24 increased p300 levels, subsequently enhancing the levels of NF-kappaB and IL-6."
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"In addition to the p300 stabilization induced by USP24 in cancer cells to regulate IL-6 expression through increased histone H3 acetylation, USP24 also reduces DNA methylation in the promoter region of IL-6 in lung cancer cells, but not in M2 macrophages, to increase IL-6 transcription by decreasing DNMT1 protein stability."
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"These results indicate that USP24 may upregulate IL-6 expression through directly stabilizing p300 and indirectly induce NF-kappaB expression through p300 in M2 macrophages."
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"In this study, we found that USP24 increased IL-6 expression by decreasing the stability of DNMT1 by stabilizing beta-TrCP in lung cancer cells and increasing the stability of p300 in both lung cancer cells and M2 macrophages, thereby resulting in the acetylation of histone H3 and demethylation of the IL-6 promoter, respectively."
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"Furthermore, USPs can control cytokine release patterns, with USP24 increasing IL-6 expression in tumor-associated macrophages (TAMs), whereas USP4, USP7, USP13, and USP19 can stabilize the release of anti-inflammatory receptors or cytokines [32–35]."
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"USP24 increases IL-6 expression by epigenetic regulation."
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"Finally, we found that knockdown of DNMT1 in USP24-knockdown A549 cells can rescue IL-6 level, suggesting that USP24 mediated DNMT1 degradation is really involved in IL-6 expression."
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"Yu et al reported that ubiquitinase RNF126 affects the TME and promotes nasopharyngeal carcinoma progression through the regulation of PTEN ubiquitination.15 Wang et al discovered that an overexpression of USP24 in M2 macrophages can promote IL-6 transcription and tumour malignancy."
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"However, USP24 promotion in M2 macrophages increases IL-6 transcription by stabilizing p300 and β-TrCP [164]."
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"In lung cancer, USP24 up-regulates the expression of IL-6, thereby promoting the development of lung cancer."
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"Here, we provide direct evidence to support that USP24 promotes IL-6 expression, which might be beneficial for cancer therapy."
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"Here, we also observed that USP24 in lung cancer cells increased IL-6 expression."
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"In this study, another interesting point is the discovery of distinct molecular mechanisms regulating IL-6 expression in M2 macrophages and lung cancer cells in response to USP24."
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"USP24 increases IL-6 transcription in M2 macrophages by stabilizing p300 and β-TrCP [164]."
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"The IL-6 levels secreted from M2 macrophages and A549 cells decreased after USP24 knockdown, suggesting that USP24 upregulation in the tumor associated microenvironment and cancer cells during tumorigenesis increased IL-6 expression."
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"Elevated USP24 in malignant cancer cells and M2 macrophages promotes metastasis by positively regulating IL-6 expression through stabilizing p300 and β-TrCP, leading to increases of histone-3 acetylation and NF-κB and decreases in DNA methyltransferase 1 (DNMT1) and IκB levels [142]."
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