IndraLab

Statements

USP24 increases the amount of IL6. 10 / 10
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"Here, we provide direct evidence to support that USP24 promotes IL-6 expression, which might be beneficial for cancer therapy."
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"In this study, another interesting point is the discovery of distinct molecular mechanisms regulating IL-6 expression in M2 macrophages and lung cancer cells in response to USP24."
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"In this study, we found that USP24 increased IL-6 expression by decreasing the stability of DNMT1 by stabilizing beta-TrCP in lung cancer cells and increasing the stability of p300 in both lung cancer cells and M2 macrophages, thereby resulting in the acetylation of histone H3 and demethylation of the IL-6 promoter, respectively."
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"Finally, we found that knockdown of DNMT1 in USP24-knockdown A549 cells can rescue IL-6 level, suggesting that USP24 mediated DNMT1 degradation is really involved in IL-6 expression."
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"USP24 increases IL-6 expression by epigenetic regulation."
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"In M2 macrophages, USP24 increased p300 levels, subsequently enhancing the levels of NF-kappaB and IL-6."
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"The IL-6 levels secreted from M2 macrophages and A549 cells decreased after USP24 knockdown, suggesting that USP24 upregulation in the tumor associated microenvironment and cancer cells during tumorigenesis increased IL-6 expression."
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"Here, we also observed that USP24 in lung cancer cells increased IL-6 expression."
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"These results indicate that USP24 may upregulate IL-6 expression through directly stabilizing p300 and indirectly induce NF-kappaB expression through p300 in M2 macrophages."
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"In addition to the p300 stabilization induced by USP24 in cancer cells to regulate IL-6 expression through increased histone H3 acetylation, USP24 also reduces DNA methylation in the promoter region of IL-6 in lung cancer cells, but not in M2 macrophages, to increase IL-6 transcription by decreasing DNMT1 protein stability."
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