IndraLab

Statements

TRX1 binds USP24. 9 / 9
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"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38 dependent inhibition of apoptosis [XREF_BIBR]."
33411764
reach
"Overall, these results support the hypothesis that pUL38 binds to USP24 to reduce ferritinophagy, which may then protect cells from lysosome dysfunction induced cell death."
29695420
sparser
"Mutant pUL38 TFV/AAA protein did not bind to USP24 and failed to prevent cell death induced by pUL38-deficient HCMV infection."
29695420
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"PUL38 binds to ubiquitin specific protease 24 (USP24), a protein that mediates autophagic ferritin degradation in lysosomes."
32765441
sparser
"HCMV pUL38 can interact with host deubiquitinase USP24 which can stabilize ferritinophagy receptor NCOA4."
35572624
sparser
"Overall, these results support the hypothesis that pUL38 binds to USP24 to reduce ferritinophagy, which may then protect cells from lysosome dysfunction induced cell death."
29695420
sparser
"USP24 regulated and stabilized the protein levels of NCOA4 thereby promoting ferritinophagy during HCMV infection, while the binding of USP24 to pUL38 was able to reduce ferritinophagy to promote iron-dependent ER stress-induced cell death ( xref ; xref )."
38075884
reach
"USP24 regulated and stabilized the protein levels of NCOA4 thereby promoting ferritinophagy during HCMV infection, while the binding of USP24 to pUL38 was able to reduce ferritinophagy to promote iron-dependent ER stress-induced cell death (Santana-Codina and Mancias, 2018; Sun et al., 2018)."
38075884
sparser
"HCMV pUL38 directly binds to USP24, and these interactions are essential for HCMV pUL38-dependent inhibition of apoptosis [ xref ]."
33411764