IndraLab

Statements

USP24 binds YAP1. 12 / 12
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"USP24 directly interacts with and deubiquitinates YAP1, thereby stabilizing YAP1 protein levels."
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"To assess the molecular mechanism through which USP24 regulates YAP1 expression, we first explored the interaction between USP24 and YAP1."
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"An interaction between endogenous USP24 and YAP1 was also validated in Bel-7402 and Huh-7 cells (Fig. 2C)."
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"Owing to the absence of structural information on the interaction between USP24 and YAP1, we generated a complex structural model of the interaction between USP24 and YAP1 by using the AlphaFold3 server [36], which provided a structural view to understand the interactions between USP24 and YAP1."
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"The interaction between USP24 and YAP1 was also confirmed to stabilize YAP1 expression through deubiquitination and activation of the downstream target genes, such as CTGF and CYR61."
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"USP24 interacts with YAP1."
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"To assess the molecular mechanism through which USP24 regulates YAP1 expression, we first explored the interaction between USP24 and YAP1."
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"Using a Co-IP assay, we examined the interactions between exogenous USP24 and exogenous YAP1 or between exogenous USP24 and endogenous YAP1, the results showed that USP24 and YAP1 were readily co-immunoprecipitated with each other (Fig.  xref A, B)."
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"An interaction between endogenous USP24 and YAP1 was also validated in Bel-7402 and Huh-7 cells (Fig.  xref C)."
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"Owing to the absence of structural information on the interaction between USP24 and YAP1, we generated a complex structural model of the interaction between USP24 and YAP1 by using the AlphaFold3 server [ xref ], which provided a structural view to understand the interactions between USP24 and YAP1."
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"The model revealed that USP24’s catalytic domain may interact with YAP1’s N-terminal region (Fig. S3B)."
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"The interaction between USP24 and YAP1 was also confirmed to stabilize YAP1 expression through deubiquitination and activation of the downstream target genes, such as CTGF and CYR61 ."
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