IndraLab

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USP24 inhibits DNMT1. 3 / 3

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"In this study, we observed that USP24 increased DNMT1 degradation in cancer cells, but not in M2 macrophages, leading to decreased DNA methylation."

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"Finally, we found that knockdown of DNMT1 in USP24-knockdown A549 cells can rescue IL-6 level, suggesting that USP24 mediated DNMT1 degradation is really involved in IL-6 expression."

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"USP24 decreases DNMT1 and IkappaB through stabilizing beta-TrCP."

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IndraLab

Statements

USP24 inhibits DNMT1. 3 / 3

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