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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP24 inhibits DNMT1. 3 / 3

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"In this study, we observed that USP24 increased DNMT1 degradation in cancer cells, but not in M2 macrophages, leading to decreased DNA methylation."

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"Finally, we found that knockdown of DNMT1 in USP24-knockdown A549 cells can rescue IL-6 level, suggesting that USP24 mediated DNMT1 degradation is really involved in IL-6 expression."

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"USP24 decreases DNMT1 and IkappaB through stabilizing beta-TrCP."

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USP24 inhibits DNMT1. 3 / 3

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