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USP24 inhibits autophagy. 13 / 13
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"Furthermore, our data demonstrate elevated levels of USP24 in some cases of idiopathic PD, suggesting that USP24 may negatively regulate autophagy in PD."
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"While the deubiquitinating enzyme USP20 and STAMBP/AMSH promote autophagy initiation by stabilizing ULK1 [21, 46], USP24 was found to negatively regulate autophagy and the stability of ULK1 [47]."
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"In addition, the level of p62/SQSTM1 was increased, not decreased, by USP24-i treatment, implying USP24-i targeting USP24 inhibits drug resistance might be through inducing p62/SQSTM1-mediated select autophagy-dependent ferroptosis."
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"Our study provides a novel therapeutic strategy to enhance the treatment response in sorafenib-resistant HCC.During sorafenib treatment, miR-21-5p, which is highly expressed in HCC, inhibits the ubiqu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP24 Negatively Regulates Autophagy through Destabilization of ULK-1."
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"Consistently, in the original screen [25] USP24 knockdown failed to upregulate autophagy in cells overexpressing BCL-2, which binds and inhibits activity of the class III PtdIns3K subunit BECN1 [34])."
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"Therefore, USP24 negatively regulates autophagy flux in human iPSC derived dopaminergic neurons, similarly to what we observed in cell lines."
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"USP24 has been reported to inhibit autophagy in neurons by increasing the degradation of ULK1 to repress the human induced-pluripotent stem cell (iPSC) differentiation into dopaminergic neurons, which is involved in Parkinson’s disease (PD) [35]."
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"Furthermore, we observed elevated levels of USP24 in the substantia nigra of a subpopulation of idiopathic PD patients, suggesting that USP24 may negatively regulate autophagy in PD."
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"In a somewhat similar manner as USP14, USP24 also negatively regulates and inhibits autophagy."
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"Therefore, a decrease in USP24 during mitosis may also induce autophagy during mitosis (Fig. 3)."
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"Our recent results indicated that USP24 knockout or USP24-i treatment induced autophagy in vivo and in vitro to inhibit the drug resistance of cancers acquired from Taxol or gefitinib treatment."
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"Our data indicate that USP24 mRNA and protein levels are also elevated in the substantia nigra of a subset of idiopathic PD patients, suggesting that suppression of autophagy by USP24 could also occur in at least some cases of non familial PD."
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