IndraLab

Statements

USP24 deubiquitinates EP300. 4 / 5
1 | 4
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"The in vitro enzymatic assay using the purified USP24 protein demonstrated that USP24 decreased the p300 ubiquitination signal (XREF_FIG)."
27991932
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"USP24 deubiquitinates and stabilizes the histone acetyltransferase p300, thereby facilitating histone H3 acetylation of the IL-6 promoter and thus IL-6 transcription."
33466790
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"Indeed, we observed that USP24 interacts with p300, and knockdown of USP24 increased p300 ubiquitination, and this effect of USP24 knockdown was abolished after treatment with the proteasome inhibitor MG132."
30266897
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"The ubiquitin hydrolase USP24 directly engages with the p300 protein, diminishing the ubiquitination of the p300 protein and its degradation through the proteasome pathway."
38056822