IndraLab

Statements

MCL1 binds USP24. 4 / 4
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"It has been observed that both USP9X and USP24 can bind to MCL-1 and enhance its stability."
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"The mechanism is that USP24-MCL-1 axis accelerates the breakdown of mitochondrial transmembrane potential and induces apoptosis."
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"Our laboratory’s previous study reported that USP24 plays an important role in the survival of T-cell acute lymphoblastic leukemia (T-ALL) cells and targeting USP24-Mcl-1 axis may represent a novel strategy in the treatment of T-ALL [ xref ]."
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"In T-ALL, USP24 exhibits a negative association with the prognosis of T-ALL and stabilizes Mcl-1 protein by deubiquitylating MCL-1 via the USP24-MCL-1 axis."
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