IndraLab

Statements

USP24 inhibits PTTG1. 2 / 2
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"In certain types of cancer, USP24 levels decrease during the early and mitotic stages of the cell cycle to regulate its substrates, including p300, BAX, E2F4, and Securin."
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"In summary, targeting USP24 by USP24-i inhibits E2F4, thereby increasing E2F1 expression, and subsequently increasing ULK1 and LC3 expression, resulting in autophagy in interphase.In previous studies, we showed that USP24 is downregulated during mitosis to destabilize securin, which will be beneficial for mitotic progression [32]."
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