IndraLab

Statements

USP24 activates sorafenib. 7 / 7
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"Consistent with a previous study discovered that USP24 regulated ferritinophagy , our results demonstrated that USP24 regulated iron metabolism thus promoting ferroptosis, and increased HCC sensitivity to sorafenib."
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"More interestingly, the upregulation of autophagy promoted the occurrence of autophagy-dependent ferroptosis in HCC, and USP24 could also increase the sensitivity of HCC to sorafenib."
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"USP24 promotes ferritinophagy and increases HCC sensitivity to sorafenib."
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"We find that increased autophagy is accompanied by ferroptosis in USP24 overexpressed HCC cells and USP24 increases the susceptibility of HCC to sorafenib."
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"To determine whether USP24 could increase the sensitivity of HCC cells to sorafenib, HCC cells were treated with different doses of sorafenib."
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"In above results, knockdown of USP24 can inhibit progress of sorafenib resistance in HCC."
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"Altogether, these results confirmed that USP24 promotes the autophagy-dependent ferroptosis and increases the sensitivity of HCC cells to sorafenib."
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