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USP24 inhibits TRAF6. 2 / 2

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"In this study, we found that targeting USP24 by the specific USP24 inhibitors, USP24-i and its analogues, dramatically activated autophagy in the interphase and mitotic periods of lung cancer cells by inhibiting E2F4 and TRAF6, respectively."

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"In summary, downregulation of USP24 during the mitotic period may increase the degradation of TRAF6, thereby increasing the protein stability of beclin-1 and leading to autophagic induction (Fig. 3I)."

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USP24 inhibits TRAF6. 2 / 2

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