IndraLab

Statements

USP24 increases the amount of PDCD1. 8 / 8
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"Furthermore, USP24 deficiency reduces PD-1 levels in CD8 + T cells and attenuates Egfr L858R -driven lung tumorigenesis in Usp24 C1695A catalytic deficient mice."
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"The knockdown screen of USP24 and other USPs showed that shUSP24 decreased PD-1 levels in Jurkat T cells, with shUSP47 and shUSPL1 showing a lesser effect (fig."
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"Notably, knockdown of USP24 (shUSP24) decreased PD-1 levels in Jurkat T cells (Fig. 2B)."
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"Moreover, ectopically expressing GFP-USP24 increased PD-1 membrane presentation, whereas knockdown of USP24 reduced the PD-1 level on the cell surface (Fig. 2C)."
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"USP24 deficiency decreased PD-1 protein expression without altering the PDCD1 mRNA level in peripheral blood mononuclear cells (PBMCs) and mouse CD8 splenic T cells (fig."
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"In addition, Usp24 depletion decreased PD-1 surface levels (Fig. 2I), resulting in increased OT-1 CD8 T antitumor activity (Fig. 2, J and K)."
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"USP24 deficiency decreased PD-1 protein expression without altering the PDCD1 mRNA level in peripheral blood mononuclear cells (PBMCs) and mouse CD8 splenic T cells (fig."
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"Together, IL-6 transcriptionally up-regulates PD-1 expression and stability mediated by USP24 in T cells within the TME.USP24 mRNA expression was up-regulated upon IL-6 treatment (Fig. 4G)."
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