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USP24 activates ferroptosis. 9 / 9
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"USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1."
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"Interestingly, we found that ferroptosis induced by USP24 is dependent on autophagy."
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"Consistent with a previous study discovered that USP24 regulated ferritinophagy , our results demonstrated that USP24 regulated iron metabolism thus promoting ferroptosis, and increased HCC sensitivity to sorafenib."
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"These findings show that USP24 upregulates NF-κB to promote ferroptosis in DCM."
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"These results suggested that USP24 promotes ferroptosis of HCC cells.Taking into account that ferroptosis is a type of autophagic cell death, which we called ferritinophagy , the Fe level was measured using a colorimetric assay and a fluorescence probe."
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"It has been shown that USP24 promotes ferroptosis by activating NF-κB in DiaCM model [214]."
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"The results indicated that overexpression of USP24 decreased GSH while increased the level of MDA in HCC cells (Fig. 7H, I and Supplementary Fig. 4G, H), further confirming that USP24 promotes ferroptosis in HCC cells."
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"Altogether, these results confirmed that USP24 promotes the autophagy-dependent ferroptosis and increases the sensitivity of HCC cells to sorafenib."
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"Our results confirmed that USP24 promotes autophagy-dependent ferroptosis by stabilizing Beclin1 (Fig. 8K)."
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