IndraLab

Statements

USP24 activates NFkappaB. 3 / 3
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"However, in this study, USP24-activated NF-κB did not increase CCL2, implying that other factors regulated by USP24 might negatively regulate CCL2 expression."
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"In this study, we discovered the underlying mechanisms by which USP24 not only promotes IkappaB degradation by stabilizing beta-transduction repeat containing E3 ubiquitin protein ligase (beta-TrCP) in lung cancer cells but also induces the upregulation of NF-kappaB in M2 macrophages, resulting in an increase in IL-6 expression."
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"This study shows that USP24 mediates p300, NF-kappaB, DNMT1, and beta-TrCP to regulate IL-6 expression, thus affecting cancer metastasis."
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