IndraLab

Statements



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"However, an interesting case-control study [86] investigating the synergistic effects of USP24, USP40, and UCH-L1 polymorphisms on PD risk in a Taiwanese population showed that a specific genotype of USP24 alone reduced PD susceptibility in subjects over the age of 60 years."

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"The USP24 T allele also seemed to reduce PD risk independently in the group> = 60 years (OR = 0.64, 95% CI 0.44-0.91, P = 0.023)."

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"Our results demonstrated that USP24 rs487230 T allele and CT/TT genotype notably decreased the risk of developing PD in the AAO> = 60 year subgroup of patients."

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"Interestingly, it has been reported that some polymorphisms of USP24 and USP40 significantly decrease the risk of developing PD [22,23]."