IndraLab

Statements

USP24 inhibits E2F4. 3 / 3
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"In certain types of cancer, USP24 levels decrease during the early and mitotic stages of the cell cycle to regulate its substrates, including p300, BAX, E2F4, and Securin."
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"In this study, we found that targeting USP24 by the specific USP24 inhibitors, USP24-i and its analogues, dramatically activated autophagy in the interphase and mitotic periods of lung cancer cells by inhibiting E2F4 and TRAF6, respectively."
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"Knockdown of USP24 decreased E2F4 protein stability (XREF_FIG; XREF_SUPPLEMENTARY)."
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