IndraLab

Statements



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"Down-regulation of USP24 but not USP9X induces growth inhibition and apoptosis of T-ALL cells."

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"Overexpression of USP24 stabilizes Securin and Bax to induce apoptosis [37]."

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"Using this deactivated CRISP-Cas9-SAM system we successfully reactivated USP24 and demonstrate that endogenously induced USP24 could partially rescue the apoptosis induced by WP1130 in Jurkat cells."

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"USP24 induces apoptosis by stabilizing p300 and Bax."

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"USP24 induces apoptosis by enhancing the stability of p300 and BAX."

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"These results indicate that USP24 promotes UV induced apoptosis in HCT116 cells, consistent with the notion that p53 directed apoptosis is attenuated in USP24 depleted cells which lack robust p53 stabilization after UV treatment."