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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

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USP24 activates apoptotic process. 4 / 4

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"USP24 induces apoptosis by stabilizing p300 and Bax."

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"Down-regulation of USP24 but not USP9X induces growth inhibition and apoptosis of T-ALL cells."

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"Using this deactivated CRISP-Cas9-SAM system we successfully reactivated USP24 and demonstrate that endogenously induced USP24 could partially rescue the apoptosis induced by WP1130 in Jurkat cells."

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"These results indicate that USP24 promotes UV induced apoptosis in HCT116 cells, consistent with the notion that p53 directed apoptosis is attenuated in USP24 depleted cells which lack robust p53 stabilization after UV treatment."

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Statements

USP24 activates apoptotic process. 4 / 4

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