Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP24 activates ubiquitinated DDB2. 2 / 2

| 2

➶

reach

"To examine if USP24 can target ubiquitinated DDB2 in vitro, we treated HeLa cells expressing Hig tagged DDB2 with MG132, a proteosome inhibitor, XREF_BIBR for 1 h and exposed HeLa cells to UVC (10 J/m 2) to stimulate DDB2 uniquitination for another hour, Ni-NTA beads were then used to pulldown modified His DDB2."

23159851

➶

reach

"Our group previously reported that ubiquitinated DDB2 can be targeted by USP24, and in this study, we demonstrate that USP24 is a p53 deubiquitinase, required for p53 stabilization in unstressed cells, as well as for p53 stabilization and PUMA activation after DNA damage."

25578727

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...