IndraLab
Statements
USP24 activates Genomic Instability. 2 / 2
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2
reach
"Increased levels of USP24 lead to p53 stabilization and upregulation and subsequent activation of p53 downstream targets.can be reversed by the action of DUBs.Thus, targeting DUBs may have promising potential in cancer therapy.9 USP24offers novel exciting perspectives in basicand translational research, and anapoptosis and genome stability."
reach
"LC3-II was significantly increased in mitotic A549 cells but not in A549-T24 cells (Fig. 3E(a), Fig. 3E(b) and Fig. 3E(d)), implying that the downregulation of USP24 may induce autophagy to maintain genomic stability in drug-sensitive lung cancer cells but not in drug-resistant lung cancer cells (Fig. 3E)."